DYSLIPIDEMIA

This study tested whether taking two medications together (JW0108 and C2407) can safely lower LDL or 'bad' cholesterol in people with dyslipidemia. A total of 145 adults participated. The main goal was to measure the percent change in LDL-C levels from the start of the study.

This study tested a new daily medication called AZD0780 in 428 adults with high cholesterol. Participants took either a low or high dose of the drug or a placebo for 12 weeks. The main goal was to see how much the drug lowered 'bad' LDL cholesterol compared to the placebo. The st…

This early-stage study tested a new drug called AZD0780 in 81 adults with high LDL ("bad") cholesterol. Participants took AZD0780 or a placebo on top of their usual cholesterol medicines like ezetimibe or statins. The goal was to see if AZD0780 safely lowers LDL more than placebo…

This study tested a drug called MCI-196 in 642 adults on dialysis who had high phosphorus and cholesterol levels. The goal was to see if the drug could safely lower these levels, which are linked to heart problems. Participants took either MCI-196 or a placebo for 12 weeks after …

This study tested two approaches—weight-focused (aiming for weight loss) and weight-neutral (focusing on physical activity without weight loss goals)—to improve metabolic health in Black adults with stage 1 obesity and related conditions like high blood pressure or prediabetes. F…

This early-stage study tested an experimental drug called ALN-APOC3 in 32 adults with dyslipidemia (abnormal blood fat levels). The main goal was to check safety and side effects, and to see how the drug changes fat levels in the blood. Participants were otherwise healthy and eit…

This study tested a medication called Cipros 10 in 146 adults with high cholesterol and triglycerides. The goal was to see if it safely lowers blood fat levels. Participants took the drug or a placebo for a set period, and researchers measured changes in triglycerides and tracked…

This early-stage study tested a single injection of a new drug called HRS-5632 in 50 healthy adults to see if it is safe and how the body processes it. The goal is to eventually treat dyslipidemia (abnormal cholesterol levels). Since it is a Phase 1 trial in healthy people, it fo…

This study tested a combination of food supplements in 80 overweight adults aged 45 and older. Over 12 weeks, researchers measured changes in cholesterol, blood sugar, and feelings of fullness. The goal was to see if these supplements could help manage weight and improve metaboli…

This study tested a lifestyle program designed for Native Hawaiian and Pacific Islander adults with conditions like prediabetes, type 2 diabetes, high blood pressure, or obesity. Community health workers delivered the program, which included support for social needs like housing …

This study examined whether people with high levels of lipoprotein (a), a type of fat in the blood, have different amounts of stem cells that help repair blood vessels. Researchers compared blood samples from 40 adults with high Lp(a) (≥100 nmol/L) to those with normal levels. Th…

This study looked at how fat particles called lipoproteins travel in the blood and how they relate to artery hardening. Researchers studied 759 people, including healthy volunteers and those with high cholesterol or other lipid disorders. Participants received injections of label…