COCAINE USE DISORDER

This early study tested whether a drug called STP7 (mavoglurant) can safely change how the body and mind react to cocaine. Twenty-one adults who used cocaine but weren't seeking treatment received either STP7 or a placebo, then were given intravenous cocaine. Researchers measured…

This study looked at whether pioglitazone, a drug used for diabetes, can help people who recently stopped using cocaine stay off the drug when combined with talk therapy. 61 adults with cocaine use disorder took part. The goal was to see if the drug improves brain health and redu…

This study tested whether psilocybin, the active ingredient in magic mushrooms, could help people quit or reduce cocaine use. Forty adults who wanted to stop using cocaine received either psilocybin or a placebo in a controlled setting. Researchers measured how many days particip…

This study tested whether a combination of two long-acting medications, naltrexone and buprenorphine, can help people reduce or stop using cocaine. Over 400 adults who wanted to cut down on cocaine use received either the drug combo or placebo injections for 8 weeks. The main goa…

This study tested whether a low dose of cariprazine, a medication used for bipolar disorder, could help people with both opioid and cocaine use disorders reduce cocaine use. Participants were already stable on buprenorphine-naloxone for opioid use. The trial lasted about 11 weeks…

This study tested whether minocycline, an antibiotic, could reduce the frequency and intensity of intrusive memories in people with PTSD or cocaine use disorder. 138 adults participated, and researchers measured changes in memory-related brain activity and self-reported distress.…

This study tested whether combining a type of brain stimulation (theta burst stimulation) with a supplement called N-acetylcysteine could lower cocaine cravings and change brain activity in response to cocaine-related images. 32 adults with cocaine use disorder participated. Rese…

This study tested whether low-intensity focused ultrasound (LIFU) can safely reduce cravings in people with cocaine use disorder. 25 adults received either real or fake (sham) ultrasound while their brain activity was measured with MRI. The goal was to see if LIFU lowers craving …

This study looked at whether the experimental drug SXC-2023 causes any safety issues when taken with cocaine. Nineteen adults who use cocaine but were not seeking treatment took either the drug or a placebo, then received cocaine in a controlled setting. Researchers measured side…

This study looked at how brain signals and thinking skills change during recovery from cocaine addiction in 63 veterans. Researchers used a behavioral treatment called contingency management, which rewards drug-free urine tests. The goal was to find brain-based clues that predict…

This study tested whether a mental exercise called Episodic Future Thinking (imagining positive future events) could help people with cocaine use disorder make better decisions and reduce cravings. 141 adults who wanted to cut down on cocaine use participated. Researchers measure…

This early-phase study looked at how changes in brain glutamate from long-term opioid use might increase cocaine use. Twelve adults with opioid and cocaine dependence took part. Researchers tested whether the supplement N-acetylcysteine (NAC) could reduce cravings and drug demand…