CARDIAC AMYLOIDOSIS

This study tests whether daily at-home weight monitoring can help people with ATTR cardiac amyloidosis avoid hospital stays for heart failure. Participants will weigh themselves each day, and a doctor will call if fluid buildup is detected. The goal is to see if this simple appro…

This study is testing a new radioactive tracer called [18F]FT8 for PET/CT scans to see if it can safely and clearly show amyloid deposits in the heart and other organs. Researchers will compare the new scan with standard tests like echocardiograms and MRIs. The study involves 20 …

This study tests whether a special PET scan using a radioactive tracer called [18F]Florbetaben can accurately diagnose cardiac AL amyloidosis, a rare condition where abnormal proteins build up in the heart. About 200 adults with suspected cardiac amyloidosis will receive one inje…

This study tests whether artificial intelligence (AI) can help doctors interpret heart ultrasound (echo) images more accurately and quickly. Researchers at Mayo Clinic will deploy AI tools to assist in diagnosing conditions like cardiomyopathy, coronary artery disease, and cardia…

This study tests whether a special PET scan using a tracer called [64Cu]FBP8 can detect blood clots inside the heart of people with cardiac amyloidosis and atrial fibrillation. Twenty participants will receive the tracer and undergo a combined PET/MRI scan. The goal is to see if …

This study is testing whether increasing the heart rate using a pacemaker can improve heart failure symptoms and exercise ability in people with cardiac amyloidosis. Ten adults who already have a pacemaker will take part. Researchers will measure changes in symptoms and heart-rel…

This study tests whether shiatsu, a type of Japanese massage, can improve symptoms like fatigue, pain, and anxiety in people with severe cardiac amyloidosis. About 108 participants will receive either targeted shiatsu or a gentle comfort version. The goal is to see if shiatsu can…

This study looks at tissue removed during back surgery to find early signs of a heart condition called transthyretin cardiac amyloidosis (ATTR-CA). Researchers will test over 1,600 adults aged 50 and older who had spine surgery. The goal is to catch the disease early, when treatm…

This study will use a special PET/MRI scan to see if it can predict serious heart events like death or hospitalization in people with cardiac amyloidosis. About 25 adults with proven amyloidosis will get one scan and then be followed for up to 2 years. The goal is to find out whi…

This study aims to improve how doctors diagnose and predict the course of rare heart muscle diseases (cardiomyopathies) using advanced MRI scans. Researchers will enroll 1000 people with suspected rare cardiomyopathies to test new imaging methods. The goal is to provide clearer, …

This study looks at how often cardiac amyloidosis occurs in people aged 80 and older who have been hospitalized for heart failure in the past year. Researchers will use bone scans to check for the condition. The goal is to better understand how widespread this disease is in older…

This study checks how common a hidden heart condition called cardiac amyloidosis is in men over 65 who have chest pain but no blocked arteries. Participants will have blood tests, heart scans, and other exams to find the condition. No treatment is given—the goal is to learn how o…

This study tests a new device that uses sound waves to measure stiffness in the heart and liver. It includes 150 adults aged 60 and older with certain types of heart failure or heart thickening, plus healthy volunteers. The goal is to see if the device can reliably detect stiffne…

This study looks at whether people with Alzheimer's disease also have harmful protein clumps (amyloid) in their hearts, which can cause heart failure. Researchers will use special PET scans—normally used to see amyloid in the brain—to also scan the heart. About 15 participants wi…

This study is testing how reproducible a special PET scan (using [18F]Florbetaben) is for detecting amyloid deposits in the heart. Researchers will scan 15 adults—some with cardiac amyloidosis and some without—twice to see if the results are consistent. The goal is to improve ima…