BRCA1 MUTATION

This study is testing an experimental drug called ETX-19477 in people with advanced solid tumors (cancers that have spread or can't be removed). The goal is to find a safe dose and see if it can shrink tumors. About 120 adults with cancers like breast, ovarian, prostate, or other…

This early-stage trial is testing a new combination of chemotherapy drugs and high-dose vitamin C, followed by an infusion of the patient's own stem cells, in people with metastatic pancreatic or breast cancer. The goal is to see if this approach is safe and can overcome drug res…

This study tests whether giving a targeted drug (olaparib) along with hormone therapy for 6 months before prostate removal surgery can improve outcomes for men with aggressive prostate cancer that has specific genetic changes (HRR gene mutations). About 32 men with unfavorable in…

This early-stage study tests whether combining two drugs, niraparib and irinotecan, is safe and effective for people with advanced solid tumors that have mutations in DNA repair genes like BRCA, ATM, or PALB2. The goal is to find the best dose with manageable side effects. About …

This early-phase study tests a combination of two oral drugs, olaparib and ASTX727, in adults with advanced solid tumors that have mutations in genes like BRCA1, BRCA2, PALB2, ATM, or CHEK2. The main goals are to find the safest dose and to check for side effects. About 18 partic…

This study is testing an experimental drug called ACE-86225106 in adults with advanced solid tumors that are difficult to treat or have stopped responding to standard therapies. The drug works by blocking a protein that helps cancer cells repair themselves, potentially slowing or…

This study tests whether adding the oral drug elacestrant to standard olaparib can help people with HR-positive, HER2-negative advanced breast cancer who have BRCA1/2 mutations. About 176 participants will be randomly assigned to receive either the combination or olaparib alone. …

This study looks at two new ways to use digital tools to help people and their families get better cancer genetic counseling. In one part, doctors will directly reach out to family members of patients with a harmful gene change to offer genetic testing, instead of relying on the …

This study looks at whether offering online genetic testing services and support to close relatives of people with BRCA mutations helps more of them get tested compared to usual care. About 820 first-degree relatives (parents, siblings, children) will take part. The goal is to se…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer. The samples will be stored and used for future research to better understand how cancer grows and responds to treatment. No direct treatment is given; the goal is …

This study aims to gather health information from 10,000 women in Italy who carry BRCA1 or BRCA2 gene mutations, which increase the risk of breast and ovarian cancers. By collecting data on where these mutations occur and how they affect health, researchers hope to improve preven…

This study tests a new educational guide to help women with BRCA mutations decide whether to take hormone replacement therapy after having their ovaries and fallopian tubes removed to lower cancer risk. About 50 premenopausal women scheduled for this surgery will receive either t…