BRCA1 MUTATION

This study tests a new laser-based blood test to see if it can detect breast cancer early. About 1,100 women will take part, including those with and without breast cancer. The goal is to see if this simple blood test works as well as mammograms for screening.

This study tests a surgery called radical fimbriectomy in women with BRCA mutations who are at high risk for pelvic cancer but want to keep their ovaries. The procedure removes the fallopian tubes, where many of these cancers start, while leaving the ovaries to produce natural ho…

This study looks at 800 people with a type of breast cancer called lobular breast cancer. Researchers are searching for inherited gene changes that may raise cancer risk. Depending on the gene found, patients may get closer monitoring or preventive surgery. The goal is to tailor …

This study checks how well the immune system works in healthy people with BRCA1 or BRCA2 gene mutations. About 50 adults over age 25 who carry these gene changes but have not had cancer will get a seasonal flu vaccine. Researchers will measure their antibody and immune cell respo…

This study looks at whether a web-based educational program can help relatives of people with BRCA1 or BRCA2 mutations understand their genetic testing options. About 240 adults who are close relatives of someone with a BRCA mutation will take part. Participants will either use t…

This study looks at how to offer BRCA gene testing to more people, especially those of Ashkenazi Jewish descent, and make it a routine part of healthcare. Over 5,400 participants will receive education before testing and can choose how to get their results. The goal is to underst…