BRCA1 MUTATION
Clinical trials for BRCA1 MUTATION explained in plain language.
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New drug duo targets Hard-to-Treat cancers in early trial
Disease control Recruiting nowThis early-phase study tests a combination of two oral drugs (olaparib and ASTX727) in adults with advanced solid tumors that have specific gene mutations (BRCA1, BRCA2, PALB2, ATM, or CHEK2). The main goals are to find the safest dose and to see if the drugs shrink tumors. About…
Matched conditions: BRCA1 MUTATION
Phase: PHASE1 • Sponsor: Pamela Munster • Aim: Disease control
Last updated Apr 29, 2026 04:46 UTC
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New drug combo before prostate surgery shows promise in early trial
Disease control Recruiting nowThis study tests whether giving a targeted drug (olaparib) plus hormone therapy for 6 months before prostate removal surgery can eliminate or shrink tumors in men with high-risk prostate cancer that has specific gene changes (HRR alterations). About 32 men will take the drugs, th…
Matched conditions: BRCA1 MUTATION
Phase: PHASE2 • Sponsor: Rana McKay, MD • Aim: Disease control
Last updated Apr 29, 2026 04:46 UTC
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10,000 women with BRCA mutations to help shape future cancer prevention
Knowledge-focused Recruiting nowThis study aims to gather health data from 10,000 women in Italy who carry BRCA1 or BRCA2 gene mutations, which increase the risk of certain cancers. By collecting information over time, researchers hope to better understand these mutations and improve how carriers are monitored …
Matched conditions: BRCA1 MUTATION
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Knowledge-focused
Last updated Apr 29, 2026 04:46 UTC