BRAIN METASTASIS

This study is for people with a specific type of lung cancer (EGFR-mutant NSCLC) that has spread to the brain. Researchers want to see if adding a precise, one-time radiation treatment (SRS) to the standard drug osimertinib is better than the drug alone at controlling brain tumor…

This study tests whether a combination of two drugs, sacituzumab tirumotecan and bevacizumab, can shrink or control brain tumors in people with triple-negative breast cancer that has spread to the brain. About 24 adults whose cancer cannot be removed by surgery or radiation will …

This study tests a new treatment using natural killer (NK) cells, a type of immune cell, for adults with aggressive brain tumors that have not responded to standard therapies. The NK cells are grown in a lab and then given through a vein and directly into the brain. The main goal…

This study tests whether giving a single dose of radiation before surgery for brain metastases can lower the chance of cancer spreading to the lining of the brain, compared to five doses after surgery. About 200 adults with brain tumors that can be removed will take part. The goa…

This study tests an oral drug called NEO212 in people with specific brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it helps control tumor growth. About 134 adults will take NEO212 alone or with sta…

This study compares two types of radiation for people with up to 5 brain metastases from solid tumors. One group gets a single high dose of radiation, the other gets three smaller doses over a week. The goal is to see which approach better controls tumors and causes fewer side ef…

This phase 2 trial tests whether using MRI-guided adaptive radiotherapy can safely eliminate extra safety margins around brain tumors, potentially reducing radiation-related brain damage. 168 adults with non-small cell lung cancer and 1-10 brain metastases will receive either the…

This study tests a new type of PET/MRI scan to see if it can better tell the difference between a growing brain tumor and changes caused by radiation or immunotherapy. About 30 adults with brain metastases who have had radiation in the last 2 years will get a single 3-hour scan s…

This study tests whether slowly reducing the dose of the steroid dexamethasone after brain tumor surgery can lower side effects like high blood sugar and poor wound healing, while still preventing brain swelling. About 200 adults with certain brain tumors will be randomly assigne…

This study tests a new program designed to help people with brain metastases manage thinking and memory problems. About 140 patients will receive different levels of support based on their needs, from educational materials to one-on-one coaching. The goal is to see if the program…

This study is testing whether a 15-minute app called Brainlab Cognition can be used in busy brain tumor clinics to track memory, attention, and other thinking skills. Researchers will also collect quality-of-life reports electronically from patients. The goal is to see if this ap…