BRAIN METASTASIS

This pilot study explores whether people with melanoma or non-small cell lung cancer that has spread to the brain can safely skip stereotactic radiosurgery (focused radiation) after having a brain tumor surgically removed. Instead of radiation, participants receive systemic thera…

This study tests whether giving pregabalin before brain tumor surgery can safely reduce pressure inside the skull. One hundred adults will receive either pregabalin or a placebo before and on the morning of surgery. Researchers will measure pressure using a painless eye ultrasoun…

This study tests whether giving higher doses of focused radiation (stereotactic radiosurgery) to brain tumors is safe and effective, without also radiating the whole brain. About 135 adults with certain types of cancer that have spread to the brain will receive escalating radiati…

This study looks at whether adding a breath-holding task to standard brain scans can make mapping of important brain areas more accurate in people with brain tumors. About 33 patients and healthy volunteers will have functional MRI scans while doing language tasks, with and witho…

This study looks at 200 people with brain tumors to see if special MRI scans can reveal details about the tumor's immune environment. Participants will have an MRI before surgery. The goal is to learn more about brain tumors, not to test a new treatment.

This study tests whether a drug called 5-ALA can make brain tumor cells glow during surgery, helping surgeons see and remove the entire tumor. About 540 adults with brain tumors will receive 5-ALA before surgery, and doctors will measure how well the glow matches actual tumor tis…