AORTIC VALVE DISEASE

This study is testing a new device called the Navitor valve, which is designed to replace a narrowed aortic heart valve without major open-heart surgery. It will enroll about 1,500 people with severe, symptomatic aortic stenosis who are considered at low or intermediate risk for …

This study is testing whether colchicine, an anti-inflammatory medication, can slow the progression of aortic valve stenosis—a serious heart condition where the main heart valve narrows. Researchers are enrolling 150 patients with moderate but symptom-free valve narrowing to see …

This study is monitoring the safety and performance of the already-approved Medtronic Avalus Ultra aortic valve in real-world patients. About 150 people in the US who need an aortic valve replacement will receive the valve and be followed for one year. The main goal is to collect…

This study is testing whether it is safe and effective for patients to be discharged from the hospital just 24 hours after a TAVI procedure, a minimally invasive heart valve replacement. It involves 585 adults with aortic valve disease who are having the procedure done through th…

This study is observing how well aortic valve replacement surgery works and how safe it is for patients in everyday hospital settings. It is following 900 adults who have had the surgery to track their health outcomes, including survival and complications, for up to five years. T…

This study aims to discover the genetic causes of diseases that weaken the body's main artery (the aorta) and affect the heart's aortic valve. Researchers are collecting blood and tissue samples from 3,000 participants, including patients with these conditions and their family me…