AMYLOIDOSIS

This study tests whether people with newly diagnosed multiple myeloma or amyloidosis who achieve a very deep response to initial drug therapy can safely postpone a stem cell transplant. About 40 participants will receive 6 cycles of a powerful drug combination (Dara-VRD). Those w…

This study tests a new treatment called AZD0120 for people with AL amyloidosis that has come back or not responded to prior therapy. The treatment uses a patient's own immune cells, modified to target and destroy harmful cells. The goal is to see if it is safe and can reduce or e…

This study tests a drug called belantamab mafodotin in people with AL amyloidosis, a rare disease where abnormal proteins build up in organs. The goal is to find the safest and most effective dose to control the disease. About 37 participants will be enrolled, and the study has t…

This program provides early access to venetoclax, a targeted therapy for several blood cancers including chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), and multiple myeloma. It is for people who have no other suitable treatments and cannot join a clinical trial…

This study tests a single dose of NTLA-2001, a gene-editing therapy, in 60 adults with hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN), a genetic disease that damages nerves. The goal is to see if the treatment can stop or slow the disease by lowering a harmfu…

This study tests whether adding an experimental drug (SCTC21C) to standard chemotherapy helps people newly diagnosed with AL amyloidosis, a rare disease where abnormal proteins build up in organs. About 90 adults will be randomly assigned to get the new combo or chemo alone. The …

This study is testing a new radioactive tracer called [18F]FT8 for PET/CT scans to see if it can safely and clearly show amyloid deposits in the heart and other organs. Researchers will compare the new scan with standard tests like echocardiograms and MRIs. The study involves 20 …

This study is testing a special radioactive tracer called I-124 evuzumitide to see if it can improve diagnosis of cardiac amyloidosis, a condition where abnormal proteins build up in the heart. About 150 adults with known or suspected amyloidosis will get a PET/MRI scan after rec…

This study tests an experimental drug called acoramidis in 587 adults who carry a gene mutation for transthyretin amyloidosis (ATTR) but have no symptoms yet. The drug aims to stabilize a protein in the blood to prevent it from forming harmful plaques in the heart and nerves. If …

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if patients prefer home care and if it is safe. Participants will receive their usual cancer drugs either at home or in the clini…

This study looks at how often amyloidosis, a rare disease where abnormal proteins build up in organs, occurs in people having trauma surgery. Researchers will check 246 patients for certain warning signs, called red flags, like age over 65 or heart issues. The goal is to find out…

This study looks at whether generative AI can help doctors better diagnose complications of rheumatoid arthritis (RA), such as lung disease or heart problems. Researchers will use AI to analyze patient records and suggest possible complications, then see if doctors find these sug…

This study is building a registry of 2,000 adults with plasma cell disorders, such as multiple myeloma and amyloidosis. Participants fill out health questionnaires and may give a blood sample to study aging markers. The goal is to gather information to help future research, not t…

This study follows 200 adults with a heart condition called ATTR amyloidosis who are taking the drug tafamidis. Researchers will check for dangerous heart rhythm problems every six months using standard tests like electrocardiograms and Holter monitors. The goal is to better unde…

This study looks at whether a new, non-invasive heart scan called magnetocardiography (MCG) can help detect and monitor amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers will compare MCG results to standard ECG in 500 adults. The goal is to see i…

This study is creating a registry of 500 people with amyloidosis to track how the disease develops, how it is treated, and how patients fare over time. Researchers will collect information on risk factors, diagnosis, treatment patterns, and survival. The goal is to better underst…

This study is creating a large database to collect information about people with rare diseases like amyloidosis, sarcoidosis, and many others. Researchers will track participants' health, treatments, and outcomes over time to better understand these conditions. The goal is to imp…

This study aims to see if a special MRI technique called magnetic resonance elastography (MRE) can measure stiffness in the hearts of people with cardiac amyloidosis, a condition where abnormal proteins build up and stiffen the heart. About 20 adults with this condition will unde…

This study is creating a biobank and data registry for people with amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers will collect blood, urine, and tissue samples along with medical information from 505 participants. The goal is to store these ma…

This study is building a registry of 5,000 adults aged 50 and older with blood cancers like multiple myeloma and lymphoma. Researchers will track frailty and other age-related health issues using surveys and simple physical tests. The goal is to learn more about this group to gui…

This study tests a new tracer for PET/CT scans that may find protein clumps (amyloidosis) in organs without needing a biopsy. It involves 30 adults with CAPS who developed amyloidosis from anakinra injections. Participants will have scans every 6 months for 2 years to track chang…