AMYLOIDOSIS

This study is testing whether adding an experimental drug called SCTC21C to a standard treatment improves outcomes for people newly diagnosed with light-chain amyloidosis, a serious disease where abnormal proteins damage organs. Researchers will compare the safety and effectivene…

This study is testing a drug called belantamab mafodotin for people with AL amyloidosis that has come back or hasn't responded to other treatments. The goal is to find a safe and effective dose and see if it can reduce the disease in the blood and improve organ function, especial…

This study is testing whether patients with newly diagnosed multiple myeloma or amyloidosis can safely delay or avoid stem cell transplant. Researchers will use a sensitive blood test to measure how well patients respond to initial drug therapy. If patients show a very deep respo…

This program provides early access to the drug venetoclax for patients with certain blood cancers like leukemia and lymphoma before it is fully approved in their country. It is for patients who have no other suitable treatment options and do not qualify for ongoing clinical trial…

This study is testing a new type of personalized cell therapy called AZD0120 in people with AL amyloidosis that has come back or hasn't responded to prior treatments. The therapy involves modifying a patient's own immune cells to target and destroy the harmful cells causing the d…

This study is testing whether a new artificial intelligence (AI) tool can help doctors more completely diagnose the many complications that can occur with rheumatoid arthritis (RA), such as lung, heart, or thyroid problems. Researchers will give doctors AI-generated predictions a…

This study is testing a new type of heart scan called magnetocardiography (MCG) to see if it can better detect and monitor amyloidosis, a disease where abnormal proteins build up in organs. Researchers will enroll 500 adults with amyloidosis to compare the new MCG scan against st…

This study is testing a new type of PET/CT scan that uses a special tracer called [18F]FT8. The goal is to see if this scan can better detect and diagnose a serious heart condition called AL amyloidosis, where abnormal proteins build up in the heart. Researchers will compare the …

This study aims to find out how common amyloidosis is among patients scheduled for trauma surgery. Researchers will screen 246 patients using a checklist of 'red flag' symptoms and medical history clues. The goal is to identify hidden cases of this protein disorder that might oth…

This study is testing a new radioactive dye used during PET/CT scans to find and track clumps of protein called amyloidosis. Amyloidosis is a rare side effect that can happen in people with a genetic immune disease (CAPS) who take the drug anakinra. Researchers want to see if thi…

This study is testing whether a new drug called acoramidis can prevent or delay heart and nerve damage in people who carry a gene for a serious disease but don't yet have symptoms. About 582 adults aged 18-75 with the genetic risk will receive either the drug or a placebo to see …

This study is testing whether cancer patients prefer to receive their standard drug treatments at home instead of in a clinic. Researchers want to see if home-based care reduces the burden of travel and improves treatment satisfaction and quality of life for patients. A specializ…

This study is creating a detailed patient registry to better understand amyloidosis, a rare disease caused by abnormal protein buildup in organs. Researchers will track 500 patients at a Buenos Aires hospital to learn about risk factors, how the disease progresses, and which trea…

This study is creating a large registry to track the health of older adults (age 50+) with blood cancers like multiple myeloma. Researchers will collect information through questionnaires and simple physical tests to understand how frailty and aging affect these patients. The goa…

This study is testing a new imaging tracer called Iodine-124 evuzumitide (AT-01) to see if it can create better pictures of where harmful amyloid proteins build up in the body, especially in the heart. Researchers will scan 150 patients with systemic amyloidosis using PET/MRI or …

This study is testing a new type of MRI scan to see if it can safely and effectively measure how stiff the heart muscle is in people with cardiac amyloidosis. Researchers will compare scans from about 20 patients who have this condition to scans from healthy people. The goal is t…

This study aims to create a large collection of biological samples and health information from people with amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers will collect blood, urine, and tissue samples, along with detailed medical records, from …

This study is creating a large registry of 2000 adults with plasma cell disorders like multiple myeloma and amyloidosis. Participants complete health assessments about their daily function, medical conditions, and quality of life over time, and can optionally give blood samples f…

This study aims to create a single, large registry to collect information on many different rare diseases. It will enroll about 380 patients already being treated at the Hospital Italiano de Buenos Aires who have one of the listed rare conditions. The goal is to gather data to be…