ALZHEIMERS DISEASE

This study tests whether a surgical procedure on lymph vessels in the neck can help people with moderate-to-severe Alzheimer's disease. The surgery is designed to improve the brain's ability to drain waste. Researchers will compare the change in dementia symptoms over 12 months b…

This study tests an experimental drug called trontinemab in 800 people with early Alzheimer's (mild memory problems to mild dementia). The goal is to see if it can slow down worsening of symptoms over 72 weeks compared to a placebo. Participants will have regular memory tests, br…

This study tests a new drug called trontinemab in 800 people with early Alzheimer's (mild memory loss to mild dementia). The goal is to see if it can slow down the disease over 72 weeks. Participants will receive either the drug or a placebo, and neither they nor their doctors wi…

This study tests a nasal spray called Foralumab in 16 people with early Alzheimer's or mild cognitive impairment. The goal is to see if it safely reduces brain inflammation and improves thinking. Participants use the spray three times a week for 8 weeks, with breaks, and are foll…

This study tests a drug called remternetug to see if it can prevent or slow Alzheimer's disease in people who have a gene mutation that causes the disease. About 280 adults with this high genetic risk will receive either the drug or a placebo. The goal is to stop harmful protein …

This study tests whether investigational drugs can prevent or slow the buildup of harmful proteins in the brain of people who carry a gene mutation that causes early-onset Alzheimer's. About 280 participants will receive either the study drug or a placebo. The goal is to see if e…

This study tests whether music therapy can alter brain-related molecules found in saliva. Researchers will compare 60 older adults—some healthy, some with mild memory issues, and some with Alzheimer's—before and after music sessions. The goal is to find scientific proof that musi…

This study looks at how people with mild cognitive impairment (MCI) or Alzheimer's disease adjust their walking to changes in their environment. Researchers will test 10 older adults using special treadmills and walking tasks to measure how well they adapt their steps. The goal i…

This study is a large pre-screening effort to identify people who may be eligible for future Alzheimer's drug trials. It will enroll up to 13,000 adults with recent memory concerns, measuring a key blood biomarker (pTau217) and cognitive performance. The goal is to efficiently ma…