ACUTE LYMPHOBLASTIC LEUKEMIA ALL

This study tests whether adding the drug bortezomib to standard chemotherapy helps children and teens with high-risk relapsed acute lymphoblastic leukemia (ALL) achieve remission and live longer. About 250 participants under 18 will be randomly assigned to receive either standard…

This study is for people with certain blood cancers (DLBCL, PMBCL, or ALL) that have not responded to at least two prior treatments. It will track how well the patient's own modified immune cells (CAR-T cells) grow and last in the body after infusion. The goal is to understand ho…

This study gives people with blood cancers, immune disorders, and other serious diseases access to unlicensed cord blood units for transplant. It includes both children and adults of any age. The main goal is to see how well the body recovers its white blood cells after the trans…

This program provides early access to venetoclax, a targeted therapy for several blood cancers including chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), and multiple myeloma. It is for people who have no other suitable treatments and cannot join a clinical trial…

This program provides access to a cancer treatment called tisagenlecleucel (Kymriah) for people with lymphoma, leukemia, or other conditions where standard treatments have failed. It is for patients who cannot join a clinical trial and have no other good options. The goal is to o…

This study is testing an improved method for cord blood transplants in adults with high-risk blood cancers like leukemia and lymphoma. The goal is to see if this optimized approach helps patients live longer and have fewer side effects. About 54 participants will receive the tran…

This study tests whether a home-based program of laughter and fun yoga can lower pain in children aged 2-10 with acute lymphoblastic leukemia who are receiving chemotherapy. Sixty children will be randomly assigned to either the laughter and yoga program plus usual care, or usual…

This study tests a small, non-invasive earbud that gently stimulates a nerve in the ear to see if it can improve sleep in adults who survived childhood leukemia and now have insomnia. About 40 participants will use either the active device or a sham (inactive) version nightly for…

This study will look back at the medical records of 18,000 children, adolescents, and young adults with cancer in low- and middle-income countries. The goal is to understand how often treatment fails or causes serious side effects, especially for acute lymphoblastic leukemia and …

This study follows 173 children aged 8-17 with acute lymphoblastic leukemia to understand how chemotherapy affects their nerves. Researchers will track symptoms like tingling or numbness over several weeks and look for factors like age, diet, or mood that might predict worse nerv…