Can targeted drugs blinatumomab and venetoclax improve outcomes for childhood leukemia?
NCT ID NCT06764238
First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This large trial is testing whether adding the targeted drugs blinatumomab or venetoclax to standard chemotherapy can improve survival and reduce side effects in children with intermediate- or high-risk B-cell acute lymphoblastic leukemia (ALL). The study compares different schedules of blinatumomab and also tests venetoclax in children who cannot receive blinatumomab. The goal is to find a more effective and less toxic treatment approach for this common childhood cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- blinatumomab and venetoclax, drugs that target cancer cells
- What this could lead to
- If successful, this could lead to more effective, less toxic treatments for childhood B-cell ALL, potentially reducing the need for transplants and improving long-term survival.
- What could go wrong
- This is an early-to-mid-stage trial, and the new drug combinations may not prove superior to standard therapy. Side effects from blinatumomab or venetoclax could be significant.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Affiliated Hospital of Qingdao University
NOT_YET_RECRUITINGQingdao, Shandong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Anhui Medical University Second Affiliated Hospital
NOT_YET_RECRUITINGHefei, Anhui, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Anhui Provincial Children's Hospital
NOT_YET_RECRUITINGHefei, Anhui, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital of Fudan University
NOT_YET_RECRUITINGShanghai, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital of Soochow University
NOT_YET_RECRUITINGSuzhou, Jiangsu, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Chongqing Medical University Affiliated Children's Hospital
NOT_YET_RECRUITINGChongqing, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fujian Medical University Union Hospital
NOT_YET_RECRUITINGFuzhou, Fujian, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Guangzhou Women and Children's Medical Center
NOT_YET_RECRUITINGGuangzhou, Guangdong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hong Kong Children's Hospital
NOT_YET_RECRUITINGHong Kong, Hong Kong
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hunan Children's Hospital
NOT_YET_RECRUITINGChangsha, Hunan, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC
RECRUITINGTianjin, Tianjin Municipality, 300020, China
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Jiangxi Provincial Children's Hospital
NOT_YET_RECRUITINGNanchang, Jiangxi, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nanfang Hospital, Southern Medical University
NOT_YET_RECRUITINGGuangzhou, Guangdong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nanjing Children's Hospital Affiliated to Nanjing Medical University
NOT_YET_RECRUITINGNanjing, Jiangsu, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Qilu Hospital of Shandong University
NOT_YET_RECRUITINGJinan, Shandong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shanghai Children's Hospital
NOT_YET_RECRUITINGShanghai, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shanghai Children's Medical Cener, Shanghai Jiao Tong University School of Medicine
NOT_YET_RECRUITINGShanghai, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shenzhen Children's Hospital
NOT_YET_RECRUITINGShenzhen, Shenzhen, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Affiliated Hospital of Guizhou Medical University
NOT_YET_RECRUITINGGuiyang, Guizhou, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The People's Hospital of Guangxi Zhuang Autonomous Region
NOT_YET_RECRUITINGNanning, Guangxi, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Third Xiangya Hospital of the Central South University
NOT_YET_RECRUITINGChangsha, Hunan, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
NOT_YET_RECRUITINGWuhan, Hubei, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
NOT_YET_RECRUITINGWuhan, Hubei, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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West China Second University Hospital, Sichuan University
NOT_YET_RECRUITINGChengdu, Sichuan, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Wuhan Children's Hospital
NOT_YET_RECRUITINGWuhan, Hubei, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Xi'an Northwest Women and Children Hospital
NOT_YET_RECRUITINGXi’an, Shanxi, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Xiangya Hospital Central South University
NOT_YET_RECRUITINGChangsha, Hunan, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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