New antibody takes aim at Hard-to-Treat blood cancers

NCT ID NCT07586618

Recruiting now Disease control Sponsor: Allterum Therapeutics, Inc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 16, 2026 · Updated 2 times

Summary

This early-stage trial tests a new antibody drug called 4A10 in 24 people with relapsed or hard-to-treat acute lymphoblastic leukemia or lymphoblastic lymphoma. 4A10 targets a protein on cancer cells to block growth signals and help the immune system attack them. The main goal is to check safety and find the right dose, with patients receiving weekly IV infusions for up to six cycles.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 4A10 (a monoclonal antibody that targets CD127 on leukemia cells)
What this could lead to: If it works, this could point toward a new targeted treatment option for people with hard-to-treat leukemia or lymphoma.
What could go wrong: This is a very early Phase 1 trial with only 24 participants, so it is primarily testing safety and dosing. The drug may not work or could have serious side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia leukemia lymphoblastic lymphoma Precursor Cell Lymphoblastic Leukemia-Lymphoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LYMPHOBLASTIC LEUKEMIA ALL LYMPHOBLASTIC LYMPHOMA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Children's Hospital Colorado
NOT_YET_RECRUITING

Aurora, Colorado, 80045, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Children's Hospital of Philadelphia
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19104, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Cook Children's Medical Center
RECRUITING

Fort Worth, Texas, 76104, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Texas Children's Hospital
NOT_YET_RECRUITING

Houston, Texas, 77030, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

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