ACUTE GRAFT-VERSUS-HOST DISEASE
Clinical trials for ACUTE GRAFT-VERSUS-HOST DISEASE explained in plain language.
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New combo therapy aims to tame Graft-Versus-Host disease after stem cell transplant
Disease control OngoingThis early-phase study tests whether combining low-dose steroids with the drug ruxolitinib can better control grade II acute graft-versus-host disease (aGVHD) after a stem cell transplant. About 30 participants with certain blood cancers will receive this combination as their fir…
Matched conditions: ACUTE GRAFT-VERSUS-HOST DISEASE
Phase: PHASE1 • Sponsor: Daihong Liu • Aim: Disease control
Last updated May 11, 2026 20:51 UTC
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Stem cell study to prevent transplant complication withdrawn before start
Disease control TerminatedThis study aimed to test whether a special type of stem cell (hAESC) could prevent a serious complication called graft-versus-host disease in people receiving a stem cell transplant for blood cancer. The plan was to give the hAESCs through an IV and monitor for side effects and h…
Matched conditions: ACUTE GRAFT-VERSUS-HOST DISEASE
Phase: PHASE1 • Sponsor: Nanfang Hospital, Southern Medical University • Aim: Disease control
Last updated May 05, 2026 11:54 UTC
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Poop pills may shield stem cell patients from deadly immune attack
Prevention OngoingThis study tests whether giving patients a fecal transplant (processed donor stool in capsules) after a stem cell transplant can prevent severe graft-versus-host disease (GVHD), a serious complication where donor cells attack the patient's body. The trial involves 138 adults who …
Matched conditions: ACUTE GRAFT-VERSUS-HOST DISEASE
Phase: PHASE2 • Sponsor: Fred Hutchinson Cancer Center • Aim: Prevention
Last updated May 17, 2026 03:16 UTC
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Probiotic shows promise in preventing deadly Graft-Versus-Host disease in kids
Prevention OngoingThis study tests whether a probiotic called Lactobacillus plantarum can prevent acute graft-versus-host disease (GvHD) in the gut of children receiving donor stem cell transplants. About 173 children with blood cancers or other conditions will take the probiotic or a placebo. The…
Matched conditions: ACUTE GRAFT-VERSUS-HOST DISEASE
Phase: PHASE3 • Sponsor: Children's Oncology Group • Aim: Prevention
Last updated May 15, 2026 11:54 UTC
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Scientists probe skin cells to unravel GVHD mystery
Knowledge-focused OngoingThis study looks at how different types of immune cells (dendritic cells) in the skin are involved in graft-versus-host disease (GVHD) after a bone marrow transplant. Researchers will collect skin samples and blood from 22 adults with acute or chronic skin GVHD to analyze cell ty…
Matched conditions: ACUTE GRAFT-VERSUS-HOST DISEASE
Sponsor: Washington University School of Medicine • Aim: Knowledge-focused
Last updated May 17, 2026 03:14 UTC
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Timing matters: new study tests if stem cell infusion time can prevent transplant complications
Knowledge-focused OngoingThis study tests whether the time of day stem cells are given affects the risk of acute graft-versus-host disease (aGVHD) in blood cancer patients receiving a stem cell transplant. About 198 patients aged 12-60 will be randomly assigned to receive their infusion at different time…
Matched conditions: ACUTE GRAFT-VERSUS-HOST DISEASE
Phase: PHASE3 • Sponsor: Anhui Provincial Hospital • Aim: Knowledge-focused
Last updated May 15, 2026 12:06 UTC