ACUTE GRAFT-VERSUS-HOST DISEASE
Clinical trials for ACUTE GRAFT-VERSUS-HOST DISEASE explained in plain language.
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Cord stem cells aim to tame transplant complication
Disease control CompletedThis study tested whether adding umbilical cord stem cells to standard steroid treatment helps control acute graft-versus-host disease (aGVHD), a serious complication after a bone marrow transplant. 26 people who developed grade II-IV aGVHD received the stem cell infusion alongsi…
Matched conditions: ACUTE GRAFT-VERSUS-HOST DISEASE
Phase: PHASE1, PHASE2 • Sponsor: Cytopeutics Sdn. Bhd. • Aim: Disease control
Last updated May 14, 2026 12:03 UTC
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Cord blood stem cells show promise against transplant complication
Disease control CompletedThis early-stage study tested whether stem cells from donated umbilical cords are safe for people with a serious complication of bone marrow transplant called graft-versus-host disease (GVHD). Twenty-four adults aged 18 to 75 received one of two doses of these stem cells. The mai…
Matched conditions: ACUTE GRAFT-VERSUS-HOST DISEASE
Phase: PHASE1 • Sponsor: University of Kansas Medical Center • Aim: Disease control
Last updated May 12, 2026 13:43 UTC
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Diabetes drug shows promise in preventing deadly transplant complication
Prevention CompletedThis study tested whether the diabetes drug sitagliptin could prevent acute graft-versus-host disease (GVHD) in 190 adults receiving stem cell transplants from partially matched donors. Participants received sitagliptin along with standard GVHD prevention. The main goal was to se…
Matched conditions: ACUTE GRAFT-VERSUS-HOST DISEASE
Phase: PHASE3 • Sponsor: The First Affiliated Hospital of Soochow University • Aim: Prevention
Last updated May 15, 2026 11:55 UTC
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Breakthrough protein may stop deadly transplant complication
Prevention CompletedThis study tested whether a protein called alpha-1 antitrypsin can prevent acute graft-versus-host disease (aGVHD) in people receiving a blood stem cell transplant for blood cancers like leukemia or lymphoma. The trial involved 222 participants aged 12 and older. The main goal wa…
Matched conditions: ACUTE GRAFT-VERSUS-HOST DISEASE
Phase: PHASE2, PHASE3 • Sponsor: CSL Behring • Aim: Prevention
Last updated May 11, 2026 20:49 UTC