ACUTE GRAFT VERSUS HOST DISEASE
Clinical trials for ACUTE GRAFT VERSUS HOST DISEASE explained in plain language.
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New drug shows promise in controlling transplant complications
Disease control CompletedThis study tested a new drug called EQ001 in 30 people who developed acute graft-versus-host disease (aGVHD) after a stem cell transplant. aGVHD is a serious condition where donor immune cells attack the patient's body. The goal was to see if EQ001 is safe and can help control th…
Matched conditions: ACUTE GRAFT VERSUS HOST DISEASE
Phase: PHASE1, PHASE2 • Sponsor: Biocon Limited • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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Can a lung drug stop transplant rejection? new trial tests Alpha-1 antitrypsin for GVHD
Disease control CompletedThis study tested whether a drug called alpha-1 antitrypsin (AAT) can prevent graft-versus-host disease (GVHD) in people receiving stem cell transplants for blood cancers. GVHD occurs when donor immune cells attack the patient's body. The trial enrolled 222 participants and compa…
Matched conditions: ACUTE GRAFT VERSUS HOST DISEASE
Phase: PHASE2, PHASE3 • Sponsor: CSL Behring • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Cord blood stem cells aim to tame transplant complication
Disease control CompletedThis early-stage study tested whether stem cells from donated umbilical cords are safe for people with a serious condition called acute graft versus host disease (aGVHD), which can happen after a bone marrow transplant. Twenty-four adults received one of two doses of these stem c…
Matched conditions: ACUTE GRAFT VERSUS HOST DISEASE
Phase: PHASE1 • Sponsor: University of Kansas Medical Center • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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Cord blood stem cells take on deadly transplant complication
Disease control CompletedThis study tested whether stem cells from donated umbilical cords (Cyto-MSC) could help treat acute graft-versus-host disease (GVHD), a serious complication after bone marrow transplants. Twenty-six patients with moderate to severe GVHD received the stem cells plus standard stero…
Matched conditions: ACUTE GRAFT VERSUS HOST DISEASE
Phase: PHASE1, PHASE2 • Sponsor: Cytopeutics Sdn. Bhd. • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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Stem cell infusion shows promise for Hard-to-Treat GVHD
Disease control CompletedThis phase 2 study tested a stem cell product called Prochymal in 11 patients with severe graft-versus-host disease (GVHD) that did not improve with standard treatments. The goal was to see if the infusion could reduce or resolve GVHD symptoms by day 28. The study measured comple…
Matched conditions: ACUTE GRAFT VERSUS HOST DISEASE
Phase: PHASE2 • Sponsor: Mesoblast, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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Can a new pill tame GVHD after transplant?
Disease control CompletedThis large Phase 3 study tested whether adding the drug itacitinib to standard steroids helps control acute graft-versus-host disease (GVHD) in people who had a stem cell transplant for blood cancer. About 439 participants received either itacitinib or a placebo along with steroi…
Matched conditions: ACUTE GRAFT VERSUS HOST DISEASE
Phase: PHASE3 • Sponsor: Incyte Corporation • Aim: Disease control
Last updated Jun 26, 2026 13:19 UTC
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New PET tracer aims to catch a dangerous transplant complication early
Diagnosis CompletedThis small Phase 1 study tested whether a radioactive tracer called [18F]F-AraG can help detect graft-versus-host disease (GVHD) using PET scans. GVHD is a serious condition where donor immune cells attack the recipient's body after a stem cell transplant. The study involved 9 pa…
Matched conditions: ACUTE GRAFT VERSUS HOST DISEASE
Phase: PHASE1 • Sponsor: CellSight Technologies, Inc. • Aim: Diagnosis
Last updated Jun 27, 2026 08:03 UTC
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New shot may shield transplant patients from deadly immune attack
Prevention CompletedThis study tested a drug called abatacept, given as a shot under the skin, to prevent a serious complication called graft-versus-host disease (GVHD) in 29 adults with blood cancers. Participants received a stem cell transplant from a half-matched donor. The goal was to see if aba…
Matched conditions: ACUTE GRAFT VERSUS HOST DISEASE
Phase: PHASE1, PHASE2 • Sponsor: The First Affiliated Hospital of Soochow University • Aim: Prevention
Last updated Jun 27, 2026 13:06 UTC
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Diabetes drug shows promise in preventing deadly transplant complication
Prevention CompletedThis study tested whether sitagliptin, a diabetes medicine, could prevent acute graft-versus-host disease (GVHD) in 190 adults receiving stem cell transplants from related or unrelated donors. Participants took sitagliptin along with standard GVHD prevention. The main goal was to…
Matched conditions: ACUTE GRAFT VERSUS HOST DISEASE
Phase: PHASE3 • Sponsor: The First Affiliated Hospital of Soochow University • Aim: Prevention
Last updated Jun 27, 2026 09:04 UTC