ABDOMINAL AORTIC ANEURYSM

This study tests a new treatment called the Nectero EAST System for people with small to medium abdominal aortic aneurysms (AAA). The goal is to see if a single treatment delivered through a catheter can stabilize the aneurysm and prevent it from growing or rupturing. About 400 p…

This study tests a special software called the Hypotension Prediction Index (HPI) that helps doctors predict and prevent low blood pressure during major aortic surgery. The trial involves 200 adults undergoing elective open or endovascular abdominal aortic surgery expected to las…

This study compares two ways to treat complex abdominal aortic aneurysms (a bulging blood vessel in the belly). One method uses a custom-made stent-graft, the other uses a stent-graft shaped with the help of a 3D-printed model of the patient's aorta. The goal is to see which appr…

This study compares two medical devices (Endurant and Excluder stent grafts) used to treat abdominal aortic aneurysms—a bulging blood vessel in the belly that can be life-threatening if it bursts. About 600 people with large aneurysms will be randomly assigned to get one of the t…

This study tests a special stent graft that doctors modify by hand to treat complex aortic aneurysms and dissections in patients who are too high-risk for standard surgery or devices. About 220 participants will be followed for up to 5 years to see if the procedure is safe and ef…

This registry is tracking the use of the PERCUTEK Tycheseal stent-graft in up to 200 patients with abdominal aortic aneurysms. The goal is to see how well the device works in everyday practice, focusing on successful deployment, freedom from leaks or rupture, and overall safety. …

This study is tracking 1,000 people who receive Terumo aortic stent grafts to repair aneurysms in the abdomen or chest. Researchers are monitoring how well the devices work and any complications, like death related to the aorta. It is an observational registry, meaning no new tre…

This study compares two different stent systems used to repair a weakened area in the main artery (aortic aneurysm). About 126 adults will be randomly assigned to receive either the BeFlared or the VBX stent during a minimally invasive procedure. The goal is to see which device t…

This early study tests a new device called the Cygnum ASMD, which is placed inside the aneurysm during standard repair surgery. The goal is to see if it is safe and can prevent type II endoleaks—small leaks that can cause the aneurysm to grow again. Fifteen adults with large abdo…

This study tests a new way to screen for abdominal aortic aneurysm (AAA), a dangerous bulge in the main belly artery that can be fatal if it bursts. Currently, patients must visit a radiologist for an ultrasound, but many don't go. Researchers are training general practitioners (…

This study tests whether adding metal coils to the aneurysm sac during standard endovascular repair (EVAR) can prevent type II endoleaks—a common complication where blood flows backward into the aneurysm. About 100 high-risk patients will be randomly assigned to receive EVAR alon…

This study is testing a new imaging drug called 64Cu-DOTA-ECL1i to see if it can show inflammation in the wall of the aorta in people with abdominal aortic aneurysms. About 30 adults with aneurysms and some without will get a PET/CT scan after receiving the drug. The goal is to u…

This study looks at whether having obstructive sleep apnea (OSA) might help protect the body from damage during surgery to fix a large blood vessel (aortic aneurysm). The idea is that the short, repeated drops in oxygen from sleep apnea might train the body to handle the stress o…

This study is testing a gel called PuraBond that helps stop bleeding during open surgery on the main artery in the belly. About 100 adults with an enlarged or blocked abdominal aorta will take part. The goal is to see how quickly the gel controls bleeding after the artery is uncl…

This early-phase study tests a new radioactive tracer called [64Cu]-RYM2 to see if it can safely and accurately detect enzyme activity in abdominal aortic aneurysms (AAA). Researchers will scan 28 people—some healthy volunteers and some AAA patients scheduled for surgery—to measu…

This Mayo Clinic study is testing two new imaging techniques to measure the strength and flexibility of the aorta in people with and without aneurysms. Researchers will use ultrasound and MRI to find areas of high stress in the vessel wall. The goal is to see if these methods are…