Yellow fever

This early-stage trial tested two new vaccines—one for yellow fever and one for rabies—in 112 healthy adults aged 18 to 40. The main goal was to check safety and see how well the vaccines trigger an immune response. Participants received different doses or a placebo to help find …

This early-stage study tested a new yellow fever vaccine (MVA-BN-YF) in 92 healthy adults aged 18-45. Some volunteers received the vaccine alone, some with an adjuvant (ISA 720) to boost the immune response, and others received a placebo or a different vaccine. The main goal was …

This study tested a new yellow fever vaccine (vYF) to see if it is as safe as the current licensed vaccine (YF-VAX). A total of 640 healthy adults aged 18 to 60 received a single shot of either vaccine. Researchers monitored side effects like pain, fever, and headache for about 6…

This study tested a yellow fever vaccine in 254 healthy adults aged 18 and older in Japan. Participants received one shot under the skin and were followed for about a month. The goal was to see if the vaccine triggers a strong immune response and is safe.

This Phase 1 study tested a new yellow fever vaccine (vYF) in 73 healthy adults aged 18 to 60. The goal was to check the vaccine's safety and how well it triggers an immune response at three different doses. Participants were monitored for side effects and antibody levels over si…

This Phase 1 trial tested an inactivated yellow fever vaccine called HydroVax-002 YFV in 26 healthy adults. Participants received two doses of either the vaccine or a placebo. The main goal was to check safety and side effects, while also measuring immune response. The trial is c…

This study tested whether smaller doses of the yellow fever vaccine are as safe and effective as the standard dose. Researchers gave 88 healthy adults either the full dose or a reduced dose (one-fifth or one-tenth the size). They monitored side effects and measured immune respons…

This pilot study tests a new technology called inDrop RNA-Seq to analyze individual immune cells in detail. Researchers will use it to study how healthy adults respond to the yellow fever vaccine, which is known to be very effective. The goal is to identify the specific cell type…

This study looked at how past infections and damage to lymph node structures might weaken the body's long-term immune response to the yellow fever vaccine. Researchers enrolled 43 healthy adults in Uganda and Minnesota, collecting blood and lymph node samples before and after vac…

This study gave 239 healthy adults the yellow fever vaccine to learn how the immune system fights viral infections. Researchers measured the strength and quality of T cell responses over up to one year. The goal was to understand immune reactions, not to test the vaccine itself, …