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Venous insufficiency
MONDO:0000945Impaired venous blood flow or venous return (venous stasis), usually caused by inadequate venous valves. Venous insufficiency often occurs in the legs, and is associated with edema and sometimes with venous stasis ulcers at the ankle.
Also known as: venous insufficiency, venous insufficiency (disease), peripheral venous insufficiency
101 clinical trials for this condition and its sub-types, 50 tagged with Venous insufficiency itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Venous insufficiency
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Chronic venous insufficiency 59 trials
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Post-thrombotic syndrome 13 trials
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New stent study aims to open blocked veins and heal leg ulcers
Disease control Not yet recruitingThis study tests a special stent (a small mesh tube) placed in veins to treat blockages, narrowing, or leg ulcers caused by poor blood flow. About 150 adults will receive the stent and be followed to see if it keeps the vein open and safe. The goal is to improve blood flow and re…
Sponsor: W.L.Gore & Associates • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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Could a daily pill ease leg pain and swelling from vein disease?
Disease control Not yet recruitingThis phase 3 trial tests whether a daily tablet of CLR-07-23 (heparan sulfate) can reduce symptoms of chronic venous disease, such as leg pain, itching, swelling, and night cramps. The study includes adults aged 18 to 80 with mild to moderate vein disease. Participants take eithe…
Phase 3 • Sponsor: Barbara Maglione • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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Cord tissue dressings aim to heal stubborn leg wounds
Disease control Not yet recruitingThis study tests whether special dressings made from donated human umbilical cord tissue, used along with standard wound care, can help close hard-to-heal leg ulcers faster than standard care alone. About 272 adults with venous leg ulcers that have not healed after 4 to 52 weeks …
Sponsor: StimLabs • Aim: Disease control
Last updated Jun 27, 2026 09:10 UTC
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Old drug, new hope: colchicine may stop Post-Clot leg damage
Disease control Not yet recruitingThis study tests whether adding colchicine, an anti-inflammatory pill, to standard blood thinners can prevent long-term vein damage after a deep vein thrombosis (DVT) in the leg. About 940 adults with a first acute DVT will receive either colchicine or a placebo for six months an…
Phase 3 • Sponsor: Azienda Sanitaria Locale ASL 6, Livorno • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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Catheter delivers numbing medicine from inside the vein to spare patients injection pain
Symptom relief Not yet recruitingResearchers are testing a new device called the Solutio™ catheter to see if it can safely deliver numbing medicine (tumescent anesthesia) from inside the great saphenous vein before endothermal ablation, a common treatment for varicose veins. The trial enrolls 30 adults with veno…
Sponsor: MedVasc AB • Aim: Symptom relief
Last updated Sep 18, 2026 00:00 UTC
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Varicose vein laser treatment moves out of the OR
Symptom relief Not yet recruitingThis study will test a new way to treat varicose veins using a 1940nm laser, performed outside the operating room under local anesthesia. Researchers want to see how satisfied patients are with the procedure and check its safety and effectiveness. About 155 adults with saphenous …
Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche • Aim: Symptom relief
Last updated Aug 27, 2026 00:00 UTC
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New study tests pill to ease pain after varicose vein procedure
Symptom relief Not yet recruitingThis study tests whether taking calcium dobesilate before and after radiofrequency ablation for varicose veins can reduce pain and improve quality of life. 250 adults with symptomatic varicose veins will be randomly assigned to receive the drug or standard care. The main goal is …
Phase 4 • Sponsor: Oguz Arslanturk • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC
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Leg vein problems may slow recovery after knee surgery
Knowledge-focused Not yet recruitingThis study will follow 100 people getting a total knee replacement to see if those with chronic venous insufficiency (poor blood flow in leg veins) have more wound healing problems. Participants will have an ultrasound before surgery to check their veins and then be monitored for…
Sponsor: SB Istanbul Education and Research Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:34 UTC
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AI takes on lymphedema: can ChatGPT help doctors diagnose and treat swelling?
Knowledge-focused Not yet recruitingThis study will test a specially trained AI model (like ChatGPT) to see if it can help doctors correctly diagnose and recommend treatments for lymphedema, lipedema, and venous insufficiency. Researchers will compare the AI's suggestions to current medical guidelines. The goal is …
Sponsor: Fatih Sultan Mehmet Training and Research Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC