Old drug, new hope: colchicine may stop Post-Clot leg damage

NCT ID NCT07432529

Not yet recruiting Disease control Sponsor: Azienda Sanitaria Locale ASL 6, Livorno Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding colchicine, an anti-inflammatory pill, to standard blood thinners can prevent long-term vein damage after a deep vein thrombosis (DVT) in the leg. About 940 adults with a first acute DVT will receive either colchicine or a placebo for six months and be followed for one year. The goal is to see if colchicine reduces the risk of post-thrombotic syndrome—a condition causing pain, swelling, and skin changes—and prevents new clots.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Colchicine (an anti-inflammatory drug) taken as a low-dose tablet
What this could lead to: If it works, this could offer a simple, low-cost way to reduce long-term leg pain and swelling after a blood clot.
What could go wrong: This is a large Phase 3 trial, but colchicine may not reduce complications and could cause side effects like stomach upset. Results are not yet available.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Inflammation post-thrombotic syndrome Postthrombotic Syndrome venous insufficiency venous thromboembolism Venous Thrombosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POST THROMBOTIC SYNDROME VENOUS INSUFFICIENCY VENOUS THROMBOEMBOLISM (VTE) VENOUS THROMBOSIS DEEP (LIMBS)

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