Tic disorder

This Phase 3 study tested whether ecopipam can safely maintain tic control in 216 people with Tourette's disorder, ages 6 and up. Participants first received open-label ecopipam, then those who responded were randomly switched to placebo or continued ecopipam to see if benefits l…

This small study tested whether Epidiolex (a prescription CBD oil) can safely reduce symptoms of obsessive-compulsive disorder, hair-pulling, Tourette syndrome, and hoarding. Four adults took the drug for two weeks. The goal was to see if symptoms improved and if the drug was wel…

This trial tests whether rhythmic electrical pulses delivered to the wrist (median nerve stimulation) can reduce tics and the urge to tic in people with Tourette syndrome or chronic tic disorder. Participants wear a portable device for 15 minutes at a time over four weeks. The st…

This study tested a drug called ecopipam in 40 children aged 7 to 17 with Tourette's syndrome. The goal was to see if it could reduce the frequency and severity of their motor and vocal tics. The drug works by blocking certain dopamine receptors in the brain. The main measure was…

This study tested whether a probiotic supplement called Lactobacillus plantarum PS128 can improve tic symptoms and quality of life in children with Tourette's syndrome. 121 children aged 4-18 took part. The main goal was to see if PS128 reduces tic severity and related emotional …

This completed study from the National Institute of Neurological Disorders and Stroke aimed to better understand how the brain controls movement and what goes wrong in movement disorders like Parkinson's disease, Tourette's syndrome, and dystonia. Over 1,200 adults—both patients …

This study looked at 132 teenagers with Tourette syndrome to understand how their brains and thinking skills change during adolescence. Researchers used brain scans (MRI), magnetic pulses (TMS), and computer tests to measure brain connections, control, and decision-making. The go…

This study looked at brain activity in the frontal cortex of 14 people with Tourette syndrome using a 24-hour portable EEG. Participants pressed a button each time they had a tic, so researchers could compare brain signals with and without tics. The goal was to identify which bra…

This completed study followed 509 children aged 3 to 18 who were taking risperidone or aripiprazole for conditions like schizophrenia or bipolar disorder. Researchers measured weight changes over up to 50 months to understand long-term risks. The goal was to provide better safety…

This completed study tested whether a short, non-invasive brain stimulation technique called theta burst stimulation (iTBS) could improve brain circuits involved in tic control. Sixteen people with Tourette syndrome, aged 10 to 21, received either real or sham stimulation. The go…

This study looked at 263 severely injured trauma patients to find out how often they develop early blood clotting problems (called trauma-induced coagulopathy) and excessive clot breakdown (hyperfibrinolysis) within the first hour of arriving at the emergency room. Researchers us…

This completed study looked at how people with Tourette syndrome perceive their own actions compared to external forces. Researchers measured a phenomenon called sensory attenuation, which reflects how the brain integrates sensory feedback with motor commands. The study involved …

This study aimed to create and test a new scale called TD-STIGMA to measure stigma and discrimination in children and young adults with chronic tic disorders, including Tourette syndrome. Researchers worked with 43 participants, including people with tics and their caregivers, to…

This study used brain scans and behavioral tests to explore why people with Tourette syndrome often act impulsively. Researchers compared 80 patients (40 on medication, 40 not) with 40 healthy volunteers. The goal was to map brain connections linked to impulsivity, which could he…