Superficial mycosis

This study tests whether adding low dose isotretinoin (a vitamin A drug) or excimer light to standard itraconazole pills works better for nail fungus. 36 adults with onychomycosis will be split into three groups: itraconazole alone, itraconazole plus isotretinoin, or itraconazole…

This study tests whether using early drug monitoring and a dose-adjustment calculator can help infants under 90 days old with sepsis reach target vancomycin levels more quickly. Currently, doctors must wait 24-48 hours to check drug levels, which can delay effective treatment. Th…

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis in the ICU. The new method adjusts the dose based on the patient's kidney function, using only standard doses. The main goal is to see if this approach is easy for doctors to use and …

This study tests a special hydrogel patch applied daily to toenails for three months. It is designed for people with nail fragility, fungal infections, or nail psoriasis. The trial includes 72 adults and compares the active patch to a placebo to see if it safely improves nail hea…

This study compares two common oral antifungal pills—fluconazole and itraconazole—in adults with ringworm that hasn't cleared up with creams. 126 people aged 18-70 with persistent infection for at least 6 months will be randomly assigned to one of the two drugs for 4 weeks. The g…

This study tests a new device that uses cold plasma (a type of energized gas) to treat moderate-to-severe athlete's foot, a stubborn fungal infection. About 220 adults with confirmed infection will receive either the plasma treatment or a fake one to see if it safely reduces skin…

This pilot study is testing whether injecting the MMR vaccine directly into skin lesions can help treat hard-to-clear fungal infections (tinea cruris and corporis). The study will enroll 50 people aged 10-60 who have not improved with standard antifungal treatments. Participants …

This study tests whether giving zinc supplements along with standard antibiotics can reduce deaths and improve recovery in young infants (0-59 days old) hospitalized with severe infections like sepsis or pneumonia. About 3,250 babies in Tanzania will receive either zinc or a plac…

This Phase 2 trial tests three different stick formulations of the antifungal drug tolnaftate (1%) for treating athlete's foot (tinea pedis). About 150 people aged 16 and older with a confirmed diagnosis will apply the stick twice daily for 4 weeks. The main goal is to see if the…

This early study tests a cream made from cassia alata, a plant, on 20 adults with tinea versicolor (light or dark patches on skin). Participants apply the cream to one area and leave another area untreated for comparison. Researchers check if the treated skin clears up better and…

This study compares two treatment schedules for oral itraconazole in children aged 5 to 18 with tinea capitis (scalp ringworm). One group takes the drug daily, the other takes it in pulses (intermittent doses). Researchers will check cure rates using clinical exams, lab tests, an…

This study compares a new medical device called ENRICHED to a standard nail fungus treatment (Loceryl) in 88 adults with nail fungus. Participants will use one of the two treatments for 9 months. Doctors will measure how much healthy nail grows back by analyzing photos. The goal …

This study tests whether pulsed electromagnetic field (PEMF) therapy can improve sports performance and speed up recovery in athletes. Thirty active adults will receive either real or fake PEMF treatments twice a week for 8 weeks. Researchers will measure cycling power, fatigue, …

This study tests whether adding a bone stimulator to standard care helps athletes aged 16–40 with a spine stress fracture (spondylolysis) heal faster, reduce pain, and return to sport sooner. About 48 participants will use the device alongside physical therapy. The goal is to see…

This study looks at how the immune system changes with age and how that affects the risk of infections in people 60 and older. Researchers will collect blood, urine, stool, and other samples from elderly patients with infections and healthy older adults. By analyzing immune cells…

This study aims to improve how doctors evaluate and manage people who have been exposed to bioterrorism agents (like anthrax) or emerging infectious diseases (like SARS or new flu strains). Up to 200 participants, including patients and healthcare workers, will be monitored and t…

This study is testing a new rapid diagnostic device called In-Dx to quickly identify infections and antibiotic resistance in emergency patients with suspected sepsis. Researchers will compare the device's results to standard lab cultures using stored samples from 2,500 patients. …

This study looks at how natural menstrual cycles and birth control pills affect strength, hydration, and energy balance in 40 female athletes. Researchers will measure muscle strength, body water, and energy use at different times of the month. The goal is to better understand ho…

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections, as well as healthy controls, …

This study looks at whether giving athletes real-time feedback during shoulder exercises helps them generate more force and do it faster. Twenty healthy, active adults will train their shoulder muscles with and without feedback to see if it makes a difference. The goal is to unde…

This study looks at how former athletes, current master's athletes, and nonathletes (ages 35-65) experience pain and respond to moderate exercise. Participants will do strength and aerobic exercises while their pain tolerance and sensitivity are measured. The goal is to understan…

This study looks at how the antibiotic ceftazidime avibactam behaves in 30 children with severe infections who are in intensive care, some on life support. Researchers will measure drug levels in the blood to understand the right dose. The goal is to improve treatment for life-th…

This study looks at whether screening college athletes for low energy availability and providing personalized nutrition advice from a sports dietitian can prevent Relative Energy Deficiency in Sport (RED-S). About 300 Division III athletes at Case Western Reserve University will …

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing needs. About 60 children in intensive …

This study will collect data from 2,000 children admitted to pediatric intensive care units (PICUs) with severe infections across major Chinese cities. Over 10 years, researchers will track which germs cause these infections, how they are treated, and patient outcomes. The goal i…

This study looks at two common antibiotic combinations given to hospitalized adults with infections: vancomycin plus piperacillin-tazobactam, or vancomycin plus cefepime. The goal is to see if one is less likely to cause kidney injury than the other, using more sensitive markers …

This study looks at how well a blood test can predict a person's fitness level, measured by VO₂max. Researchers will collect blood samples and fitness data from 250 healthy adults. The goal is to see if certain molecules in the blood can accurately estimate how fit someone is, an…

This study compares two types of visual cues during treadmill walking in 36 athletes who had ACL reconstruction. One cue is a steady beat (isochronous), the other has natural fluctuations (fractal). The goal is to see which better restores natural walking patterns and brain activ…

This study looks at how different warm-up exercises affect the performance of young competitive swimmers. Fifteen athletes will try three different warm-up routines, and researchers will measure their jump height and swim times for 25, 50, and 100 meters. The goal is to find the …

This pilot study is testing whether a smart wristband can accurately measure drug levels in sweat compared to standard blood tests. Researchers will collect sweat, saliva, and blood samples from 100 patients with chronic or infectious diseases who are taking medications like cycl…

This study is looking for new ways to diagnose sepsis, a life-threatening reaction to infection, earlier in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve diagno…