Stiff-person syndrome
MONDO:0008491Stiff-man syndrome (SMS) is a rare neurological disorder comprising fluctuating trunk and limb stiffness, painful muscle spasms, task-specific phobia, an exaggerated startle response, and ankylosing deformities such as fixed lumbar hyperlordosis.
Also known as: Moersch-Woltman syndrome, Stiff Person Syndrome, Stiff Person syndrome, Stiff-man syndrome, stiff-person syndrome, Morsch Woltman syndrome, SMS, SPS
10 clinical trials for this condition and its sub-types.
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Spinal zap trial offers hope for rare stiffness disease
Symptom relief CompletedThis small pilot study tested whether spinal cord stimulation could reduce painful muscle rigidity and spasms in people with stiff person syndrome, a rare autoimmune condition. Two adults with the disease received temporary stimulation for up to 10 days, and researchers measured …
Phase: NA • Sponsor: Wake Forest University Health Sciences • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
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No more clinic trips? telerehab shows promise for knee arthritis pain
Symptom relief CompletedThis study tested whether a telerehabilitation program—where patients do exercises at home with remote support from a physiotherapist via video calls, phone, and texts—can reduce pain and improve knee function in people with knee osteoarthritis. 118 patients aged 50 and older wit…
Phase: NA • Sponsor: University of Novo Mesto • Aim: Symptom relief
Last updated Jun 27, 2026 08:08 UTC