Stiff-person syndrome
MONDO:0008491Stiff-man syndrome (SMS) is a rare neurological disorder comprising fluctuating trunk and limb stiffness, painful muscle spasms, task-specific phobia, an exaggerated startle response, and ankylosing deformities such as fixed lumbar hyperlordosis.
Also known as: Moersch-Woltman syndrome, Stiff Person Syndrome, Stiff Person syndrome, Stiff-man syndrome, stiff-person syndrome, Morsch Woltman syndrome, SMS, SPS
12 clinical trials for this condition and its sub-types.
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Broader categories
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Experimental CAR T-Cell therapy targets rare stiff person syndrome
Disease control CompletedThis phase 2 trial is testing a new treatment called KYV-101 for people with stiff person syndrome (SPS) that hasn't improved with standard therapies. The treatment uses a patient's own immune cells, modified to target and attack certain immune cells that may be causing the disea…
Phase 2 • Sponsor: Kyverna Therapeutics • Aim: Disease control
Last updated Jul 26, 2026 00:00 UTC
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Spinal zap trial offers hope for rare stiffness disease
Symptom relief CompletedThis small pilot study tested whether spinal cord stimulation could reduce painful muscle rigidity and spasms in people with stiff person syndrome, a rare autoimmune condition. Two adults with the disease received temporary stimulation for up to 10 days, and researchers measured …
Sponsor: Wake Forest University Health Sciences • Aim: Symptom relief
Last updated Sep 02, 2026 00:00 UTC
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No more clinic trips? telerehab shows promise for knee arthritis pain
Symptom relief CompletedThis study tested whether a telerehabilitation program—where patients do exercises at home with remote support from a physiotherapist via video calls, phone, and texts—can reduce pain and improve knee function in people with knee osteoarthritis. 118 patients aged 50 and older wit…
Sponsor: University of Novo Mesto • Aim: Symptom relief
Last updated Jun 27, 2026 08:08 UTC