Stiff-person syndrome
MONDO:0008491Stiff-man syndrome (SMS) is a rare neurological disorder comprising fluctuating trunk and limb stiffness, painful muscle spasms, task-specific phobia, an exaggerated startle response, and ankylosing deformities such as fixed lumbar hyperlordosis.
Also known as: Moersch-Woltman syndrome, Stiff Person Syndrome, Stiff Person syndrome, Stiff-man syndrome, stiff-person syndrome, Morsch Woltman syndrome, SMS, SPS
12 clinical trials for this condition and its sub-types.
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Broader categories
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Tiny trial hopes blood filtering eases rare stiff person syndrome
Disease control CancelledThis early pilot study will test the safety of a procedure called extracorporeal photopheresis (ECP) in just 3 adults with stiff person syndrome. ECP involves filtering a person's blood, treating it with light and a drug, then returning it to the body. The goal is to see if patie…
Early phase 1 • Sponsor: Yandy Marx Castillo Aleman • Aim: Disease control
Last updated Aug 08, 2026 00:03 UTC
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Space suit that zaps muscles could keep astronauts fit on mars missions
Disease control By invitation onlyThis study tests a special body suit that uses gentle electric pulses to stimulate muscles, helping astronauts exercise more efficiently in space. Twelve astronauts on the International Space Station will wear the suit during their workouts. Researchers will measure muscle stiffn…
Sponsor: Charite University, Berlin, Germany • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Engineered immune cells take on lupus and scleroderma in early trial
Disease control By invitation onlyThis early-phase study tests a new treatment called Prula-cel for people with autoimmune diseases like lupus, scleroderma, and vasculitis. Prula-cel uses donor immune cells engineered to target and destroy faulty immune cells that attack the body. The goal is to find a safe dose …
Phase 1 • Sponsor: Adicet Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
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Could a stem cell transplant stop the immune system from attacking the brain?
Disease control OngoingThis phase 2 trial tests whether high-dose chemotherapy followed by a stem cell transplant can stop the immune system from attacking the nervous system in people with autoimmune neurologic diseases like multiple sclerosis and stiff person syndrome. The treatment aims to weaken th…
Phase 2 • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC