Stiff-person syndrome
MONDO:0008491Stiff-man syndrome (SMS) is a rare neurological disorder comprising fluctuating trunk and limb stiffness, painful muscle spasms, task-specific phobia, an exaggerated startle response, and ankylosing deformities such as fixed lumbar hyperlordosis.
Also known as: Moersch-Woltman syndrome, Stiff Person Syndrome, Stiff Person syndrome, Stiff-man syndrome, stiff-person syndrome, Morsch Woltman syndrome, SMS, SPS
10 clinical trials for this condition and its sub-types.
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Broader categories
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Experimental CAR-T therapy targets Hard-to-Treat brain autoimmune diseases
Disease control Not yet recruitingThis early-stage trial is testing a new treatment called C-CAR168, which uses a patient's own immune cells modified to attack harmful cells in the body. It is for 15 adults with multiple sclerosis, neuromyelitis optica, autoimmune encephalitis, or stiff person syndrome that have …
Phase: PHASE1 • Sponsor: Huashan Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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Tiny trial hopes blood filtering eases rare stiff person syndrome
Disease control Not yet recruitingThis early pilot study will test the safety of a procedure called extracorporeal photopheresis (ECP) in just 3 adults with stiff person syndrome. ECP involves filtering a person's blood, treating it with light and a drug, then returning it to the body. The goal is to see if patie…
Phase: EARLY_PHASE1 • Sponsor: Yandy Marx Castillo Aleman • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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New hope for stiff person syndrome: drug trial aims to ease muscle stiffness and improve walking
Symptom relief Not yet recruitingThis study tests a medicine called IGIV 10% (a type of antibody treatment) against a placebo in 38 adults aged 18-70 with Stiff Person Syndrome, a rare condition causing muscle stiffness and spasms. The main goal is to see if the drug helps people walk faster (measured by a 25-fo…
Phase: PHASE3 • Sponsor: Kedrion S.p.A. • Aim: Symptom relief
Last updated Jun 27, 2026 13:06 UTC