Experimental CAR T-Cell therapy targets rare stiff person syndrome
NCT ID NCT06588491
First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 3 times
Summary
This phase 2 trial is testing a new treatment called KYV-101 for people with stiff person syndrome (SPS) that hasn't improved with standard therapies. The treatment uses a patient's own immune cells, modified to target and attack certain immune cells that may be causing the disease. The study will enroll 25 participants to see if the therapy can improve walking speed and reduce symptoms, while also monitoring for side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- KYV-101 (a type of CAR T-cell therapy made from the patient's own immune cells, targeting CD19)
- What this could lead to
- If successful, this could offer a new treatment option for people with stiff person syndrome that hasn't responded to other therapies, potentially improving mobility and reducing symptoms.
- What could go wrong
- This is an early-phase trial with only 25 participants, so results may not apply to everyone. CAR T-cell therapy can cause serious side effects like cytokine release syndrome and neurological problems.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107, United States
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University of Colorado Anschutz Medical Campus
Aurora, Colorado, 80045, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- CAR T-Cell therapy: what happens years later?
- Experimental CAR-T therapy targets Hard-to-Treat brain autoimmune diseases