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Stiff-person syndrome

MONDO:0008491

Stiff-man syndrome (SMS) is a rare neurological disorder comprising fluctuating trunk and limb stiffness, painful muscle spasms, task-specific phobia, an exaggerated startle response, and ankylosing deformities such as fixed lumbar hyperlordosis.

Also known as: Moersch-Woltman syndrome, Stiff Person Syndrome, Stiff Person syndrome, Stiff-man syndrome, stiff-person syndrome, Morsch Woltman syndrome, SMS, SPS

10 clinical trials for this condition and its sub-types.

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Sub-types

Classic stiff person syndrome (0) Focal stiff limb syndrome (0) Progressive encephalomyelitis with rigidity and myoclonus (0)

Broader categories

Disease (618) Nervous system disorder (217) Syndromic disease (24) Human disease (14) Disease by body system or component (0)
Trials to join now! 1 Not yet recruiting 3 Not yet finished but already full! 4 Completed 2
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    Knowledge-focused Recruiting now

    This study follows about 70 people who have already received KYV-101, a CAR T-cell therapy, for autoimmune diseases like lupus and multiple sclerosis. Researchers will monitor participants for up to 15 years to track any delayed side effects, new cancers, or other health problems…

    Sponsor: Kyverna Therapeutics • Aim: Knowledge-focused

    Last updated Jun 27, 2026 09:05 UTC

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