Squamous cell intraepithelial neoplasia

This study tests whether a probiotic called EXE-346 can help treat anal high-grade squamous intraepithelial lesions (HSIL) and reduce persistent high-risk HPV infection in people living with HIV. The trial will enroll 90 participants who will take the probiotic or a placebo daily…

This early-stage trial tests whether curcumin (the active ingredient in turmeric) can reverse high-grade anal precancerous lesions in people living with HIV. Participants insert curcumin capsules into the anus daily for 14 days. The main goal is to find the safest dose, not yet t…

This early-stage trial tests two vaccines designed to help the immune system fight HPV16, a virus linked to cervical cancer. The study includes 30 women with persistent HPV16 infection and mild cervical cell changes (ASC-US or LSIL). Participants receive a DNA vaccine followed by…

This study tests whether a vaginal suppository called Dysplasix can help women clear high-risk human papillomavirus (HPV) and reverse low-grade cervical abnormalities. About 45 women with HPV and mild cervical changes will use the suppository or a placebo for 19 days. Researchers…

This early-stage study tests whether a cream made from two HIV drugs (lopinavir/ritonavir) can be safely placed inside the anus to treat high-grade anal growths (AIN 2/3) in people living with HIV. About 21 participants will receive the cream for a few months and be followed for …

This study tests an experimental treatment called NWRD08 in 150 women with high-grade cervical lesions (CIN2/3) caused by HPV types 16 or 18. The treatment is given as a shot followed by a quick electrical pulse to help it enter cells. The goal is to see if it can shrink or elimi…

This study looks at different screening methods to find anal precancer in people at high risk, such as those with weakened immune systems or a history of certain genital cancers. Researchers will compare tests like high-resolution anoscopy, HPV testing, and cell samples to see wh…

This study evaluates whether an HPV DNA test can more accurately detect pre-cancerous cervical changes than standard Pap smears in 1,500 women in South Africa, including those with and without HIV. Participants undergo HPV testing, followed by colposcopy and biopsy if needed. The…

This study compares the standard Pap smear with a new blood test that looks for three proteins to detect early cervical changes and cancer. About 558 women aged 18-85 will participate. The goal is to see if the blood test is as good or better at finding problems early.

This study tests a portable microscope with artificial intelligence to help doctors spot early signs of esophageal cancer during a routine scope exam. Researchers will enroll 200 adults in Brazil and the United States who are already scheduled for screening. The goal is to see if…

This study collects blood, bone marrow, and tissue samples from people with HIV, KSHV, or certain cancers to help researchers learn more about these diseases. Participants must be 18 or older and may have HIV, KSHV, or related conditions. No treatment is given; the goal is to gat…

This study looks at anal cancer risk in men who have sex with men (MSM) who take PrEP to prevent HIV. Researchers want to find out how common high-grade anal lesions are, how well anal swabs detect them, and how these lesions affect quality of life. About 296 participants will an…