Skin pigmentation disorder

This study tested a drug called alemtuzumab (Campath) as a first treatment for children with hemophagocytic lymphohistiocytosis (HLH), a rare and life-threatening immune disorder. The goal was to see if it could help children survive until they could receive a stem cell transplan…

This study tested a drug called pegcetacoplan in 124 adults and teens with two rare kidney diseases (C3G and IC-MPGN). The goal was to see if the drug could reduce protein in the urine, a sign of kidney damage. Participants received either the drug or a placebo twice a week for 2…

This study tested seven different cosmetic creams to see if they could prevent skin darkening caused by high-energy visible light (like from the sun or screens). 33 healthy adults with fair to medium skin had creams applied to their back before being exposed to a specific blue-vi…

This study tests whether tranexamic acid, a drug used to control bleeding, can prevent dark spots that often appear after skin inflammation. Ten healthy men at risk for hyperpigmentation will take the drug and have small blisters created on their skin to trigger the spots. Resear…

This 4-week pilot study tested two brightening serums against 4% hydroquinone in 18 adults with hyperpigmentation or melasma. Each participant used different products on each side of their face to compare results. The goal was to see if the serums could improve skin tone evenness…

This completed study tested a brightening treatment (a type of chemical peel) combined with a retinol serum and post-procedure cream on 11 healthy women aged 20 to 65 with moderate facial pigmentation from sun exposure or blemishes. Participants received four treatment sessions t…

This study tested a dark spot corrector serum along with two different skincare routines in 48 women with moderate age spots. Over 16 weeks, doctors checked if the spots got lighter, smaller, or less noticeable. The goal was to see if the treatment was safe and effective for impr…

This study tested a combination of light and laser treatments on 15 adults with skin pigmentation and texture issues from sun damage. Participants received up to two treatments using the Sciton Joule System, which combines broad-based light, fractionated laser, and dual-wavelengt…

This study tested two stress and symptom management programs for adults with neurofibromatosis (NF1, NF2, or schwannomatosis). The programs were delivered through live videoconferencing over 8 weekly sessions. Researchers measured changes in quality of life and emotional well-bei…

This study tested a special laser (1927nm) to reduce dark spots on the face in 15 adults with Fitzpatrick Skin Types V and VI (darker skin). The goal was to see if the laser works and to find the best skin care routine before and after treatment to avoid side effects like scarrin…

This study tested whether special face creams can improve skin tone and reduce dark spots. 250 women used the products on their whole face for 12 weeks. Researchers checked skin color and glow by sight and with instruments, and also looked at changes in skin bacteria.

This study looked at whether washing fat with saline before injecting it into the face improves skin appearance more than using unwashed fat. Twenty-six healthy women aged 35 to 70 with visible signs of aging received fat grafts on both sides of their face. Researchers measured c…

This study looks at people with neurofibromatosis type 1 (NF1) and their families to find out why some have more severe symptoms than others. Researchers will collect medical history, blood samples, and images to study genes and physical traits. The goal is to identify genes that…

This study investigates people with oculocutaneous albinism who have no known genetic cause for their condition. Researchers use advanced DNA analysis techniques to search for new or hidden mutations. The goal is to improve diagnosis and understanding of this inherited condition.

This study looked back at 120 people who had lower eyelid surgery to remove bags. Researchers wanted to see how the surgery affected dark circles and wrinkles around the eyes months to years later. They used photos and rating scales to measure changes in skin color and wrinkle se…

This study tested an artificial intelligence algorithm designed to help primary care doctors decide whether a patient with a skin condition really needs to see a dermatologist. Researchers enrolled 200 adults with skin problems and had their doctors take photos of the affected ar…