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Severe combined immunodeficiency

MONDO:0015974

Severe combined immunodeficiency (SCID) comprises a group of rare monogenic primary immunodeficiency disorders characterized by a lack of functional peripheral T lymphocytes resulting in early-onset severe respiratory infections and failure to thrive. They are classified according to immunological phenotype into SCID with absence of T cells but presence of B cells (T-B+ SCID) or SCID with absence of both (T-B- SCID). Both of these groups include several forms, with or without natural killer (NK) cells.

Also known as: SCID, severe combined immunodeficiency, severe combined immunodeficiency (disease), severe combined immunodeficiency disease

48 clinical trials for this condition and its sub-types.

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Sub-types

T-B+ severe combined immunodeficiency due to gamma chain deficiency (10) Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency (6) Omenn syndrome (4) Severe combined immunodeficiency due to DCLRE1C deficiency (3) T-B+ severe combined immunodeficiency due to JAK3 deficiency (2) DNA ligase IV deficiency (1) MHC class II deficiency (1) Reticular dysgenesis (1) Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive (1) T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency (1) Cernunnos-XLF deficiency (0) Combined immunodeficiency due to partial RAG1 deficiency (0) Combined immunodeficiency with skin granulomas (0) Combined immunodeficiency, X-linked (0) Familial severe combined immunodeficiency (0) Immunodeficiency 104 (0) Immunodeficiency 105 (0) Immunodeficiency 18 (0) Immunodeficiency 19 (0) Immunodeficiency 25 (0)

Broader categories

Disease (618) Hereditary disease (172) Immune system disorder (140) Immunodeficiency disease (48) Human disease (14) Combined immunodeficiency (3) Disease of genetic or genomic mechanism (2) Disease by body system or component (0) Disease by etiologic mechanism (0)
Trials to join now! 27 Not yet finished but already full! 14 Completed 6 Terminated 1
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