Severe combined immunodeficiency
MONDO:0015974Severe combined immunodeficiency (SCID) comprises a group of rare monogenic primary immunodeficiency disorders characterized by a lack of functional peripheral T lymphocytes resulting in early-onset severe respiratory infections and failure to thrive. They are classified according to immunological phenotype into SCID with absence of T cells but presence of B cells (T-B+ SCID) or SCID with absence of both (T-B- SCID). Both of these groups include several forms, with or without natural killer (NK) cells.
Also known as: SCID, severe combined immunodeficiency, severe combined immunodeficiency (disease), severe combined immunodeficiency disease
38 clinical trials for this condition and its sub-types, 24 tagged with Severe combined immunodeficiency itself.
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Sub-types of Severe combined immunodeficiency
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Familial severe combined immunodeficiency 0 trials · 22 incl. sub-types
14 sub-types
- T-B+ severe combined immunodeficiency due to gamma chain deficiency 10 trials
- Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency 6 trials
- Omenn syndrome 4 trials
- Severe combined immunodeficiency due to DCLRE1C deficiency 3 trials
- T-B+ severe combined immunodeficiency due to JAK3 deficiency 2 trials
- Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive 2 trials
- MHC class II deficiency 1 trial Sub-types →
- Reticular dysgenesis 1 trial Sub-types →
- Cernunnos-XLF deficiency 0 trials
- Immunodeficiency 104 0 trials
- Immunodeficiency 105 0 trials
- Immunodeficiency 18 0 trials
- Immunodeficiency 19 0 trials
- Immunodeficiency 49 0 trials
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T-B- severe combined immunodeficiency 0 trials · 14 incl. sub-types
16 sub-types
- Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency 6 trials
- Omenn syndrome 4 trials
- Severe combined immunodeficiency due to DCLRE1C deficiency 3 trials
- Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive 2 trials
- DNA ligase IV deficiency 1 trial
- Reticular dysgenesis 1 trial Sub-types →
- Cernunnos-XLF deficiency 0 trials
- Combined immunodeficiency due to partial RAG1 deficiency 0 trials
- Combined immunodeficiency with skin granulomas 0 trials
- Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia 0 trials
- Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia 0 trials
- Neutrophil immunodeficiency syndrome 0 trials
- Reticular dysgenesis-like severe combined immunodeficiency 0 trials
- Severe combined immunodeficiency due to DNA-PKcs deficiency 0 trials
- Severe combined immunodeficiency due to LCK deficiency 0 trials
- Short-limb skeletal dysplasia with severe combined immunodeficiency 0 trials
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T-B+ severe combined immunodeficiency 0 trials · 10 incl. sub-types
10 sub-types
- T-B+ severe combined immunodeficiency due to gamma chain deficiency 10 trials
- T-B+ severe combined immunodeficiency due to JAK3 deficiency 2 trials
- T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency 1 trial
- T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta 0 trials Sub-types →
- T-B+ severe combined immunodeficiency due to CD45 deficiency 0 trials
- Combined immunodeficiency, X-linked 0 trials
- Immunodeficiency 104 0 trials
- Lung fibrosis-immunodeficiency-46,XX gonadal dysgenesis syndrome 0 trials
- Severe combined immunodeficiency due to CORO1A deficiency 0 trials
- Severe combined immunodeficiency due to LAT deficiency 0 trials
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2 sub-types
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Immunodeficiency 79 0 trials
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Janus kinase-3 deficiency 0 trials
Most studied deeper sub-types
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Gene therapy offers hope for babies with 'Bubble Boy' disease
Cure Recruiting nowThis study tests a new gene therapy for children with a severe immune disorder called Artemis-SCID, where the body cannot fight infections. Doctors take the child's own blood stem cells, fix the faulty gene in a lab, and put the corrected cells back. The goal is to rebuild a work…
Phase 1/2 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Cure
Last updated Jun 27, 2026 12:00 UTC
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Stem cell transplant offers new hope for rare immune diseases
Disease control Recruiting nowThis study tests a stem cell transplant for people with common variable immunodeficiency (CVID) and other immune disorders. The goal is to replace the faulty immune system with a healthy donor's stem cells. Participants are aged 5 to 40 and will receive a reduced-intensity transp…
Phase 2 • Sponsor: Paul Szabolcs • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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New stem cell filter could make transplants safer for vulnerable patients
Disease control Expanded accessThis expanded access program offers a special stem cell purification technique (CD34+ selection) for patients undergoing stem cell transplants. The method removes many T-cells from the donated stem cells, which lowers the risk of a serious complication called graft-versus-host di…
Sponsor: University of Florida • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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Gene therapy offers new hope for babies with rare 'Bubble Boy' disease
Disease control Recruiting nowThis study tests a gene therapy for Artemis-deficient severe combined immunodeficiency (ART-SCID), a life-threatening immune disorder. It involves taking the patient's own blood stem cells, adding a working copy of the faulty gene, and infusing them back after mild chemotherapy. …
Phase 1/2 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Milder chemo before stem cell transplant shows promise for rare blood disorders
Disease control Recruiting nowThis study tracks 50 children and adults with non-malignant disorders like immune deficiencies and anemias who receive a stem cell transplant after a reduced-intensity chemotherapy regimen. The goal is to see if this approach improves survival and reduces severe graft-versus-host…
Sponsor: Paul Szabolcs • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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Milder transplant method aims to help young patients with rare blood diseases
Disease control Recruiting nowThis study is testing a less intense chemotherapy and radiation regimen before a stem cell transplant for children and young adults up to age 55 with non-cancerous blood disorders like immune deficiencies, anemias, and metabolic diseases. The goal is to see if this gentler prepar…
Phase 2 • Sponsor: Paul Szabolcs • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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Could a simple gas ease breathing for spinal cord injury patients?
Symptom relief Recruiting nowThis study tests whether daily treatments with slightly elevated carbon dioxide (hypercapnia) can improve breathing and reduce sleep apnea in Veterans with spinal cord injury. About 30 adults with chronic spinal cord injury or able-bodied people with sleep apnea will receive the …
Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated Jun 27, 2026 12:03 UTC
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Scientists hunt for genetic clues behind rare immune disorder
Knowledge-focused Recruiting nowThis study aims to find the genetic causes of severe combined immunodeficiency (SCID), a rare condition where the immune system doesn't work properly. Researchers will collect blood samples from 100 patients and their relatives to analyze DNA and other factors. The goal is to bet…
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Sep 03, 2026 00:00 UTC
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Gut virus linked to liver damage in immune-deficient patients?
Knowledge-focused Recruiting nowThis study looks at 120 people with various immune deficiencies to see if a chronic gut virus infection is tied to liver or digestive problems. Researchers will collect blood, stool, urine, and biopsy samples to screen for enteric viruses. The goal is to identify which patients a…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC