Recombinase activating gene 2 deficiency

MONDO:0000573

A severe combined immunodeficiency that is the result of a mutation on Chromosome 6 RAG2 gene involving genetic rearrangement of both the T- and B-lymphocyte receptor genes.

Also known as: recombinase activating gene 2 deficiency

2 clinical trials for this condition and its sub-types, 0 tagged with Recombinase activating gene 2 deficiency itself.

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Where it sits in the disease tree

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Part of

↑ Severe combined immunodeficiency (37)

Including sub-types (2) Tagged with Recombinase activating gene 2 deficiency (0)

Completed 1 Terminated 1

Bubble baby breakthrough? experimental cell shot aims to reboot immune system faster

Disease control Completed

This early-phase trial tested whether injecting special immune-building cells (HTLPs) could help children with severe combined immunodeficiency (SCID) rebuild their immune system faster after a partially matched stem cell transplant. Only 4 children took part. The goal was to see…

Phase 1/2 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control

Last updated Jun 27, 2026 12:36 UTC

Recombinase activating gene 2 deficiency

Where it sits in the disease tree

Bubble baby breakthrough? experimental cell shot aims to reboot immune system faster