Bubble baby breakthrough? experimental cell shot aims to reboot immune system faster

NCT ID NCT03879876

Completed Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tested whether injecting special immune-building cells (HTLPs) could help children with severe combined immunodeficiency (SCID) rebuild their immune system faster after a partially matched stem cell transplant. Only 4 children took part. The goal was to see if the injection was safe and if it led to quicker recovery of T-cells, which fight infections.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Human T Lymphoid Progenitor (HTLP) injection
What this could lead to: If it works, this could help children with SCID rebuild their immune system faster after a stem cell transplant, reducing infection risk.
What could go wrong: This was a very small, early-phase trial with only 4 patients. The approach is still experimental and may not work for everyone. Risks include side effects from the injection or transplant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ANY TYPE OF SEVERE COMBINED IMMUNODEFICIENCY (SCID) are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

severe combined immunodeficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANY TYPE OF SEVERE COMBINED IMMUNODEFICIENCY (SCID) PARTIAL HLA INCOMPATIBLE ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT) PEDIATRIC PATIENTS

Contacts and locations

Locations

Unité d'Immunologie Hématologie Rhumatologie Pédiatrique (UIHR),

Paris, Île-de-France Region, 75015, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.