Serositis

This study tests whether ulinastatin, a drug that reduces inflammation, can help patients with severe abdominal infections. The infection often causes the immune system to overreact, leading to organ failure and high risk of death. Researchers will give patients either a low or h…

This pilot study tests whether silver-impregnated dressings can effectively manage catheter exit-site or tunnel infections in adults on peritoneal dialysis. Sixty participants will be randomly assigned to receive either the silver dressing or standard daily antibiotic dressings, …

This study looks at whether adding L-carnitine, a natural substance, to standard care can improve outcomes for critically ill adults with liver disease in the ICU. About 58 participants with conditions like liver failure or severe infections will be enrolled. Researchers will tra…

Rheumatoid arthritis and gout can look alike, making them hard to tell apart early. This study will use ultrasound to see if it can reliably distinguish between the two conditions. Researchers will examine 100 adults with suspected or confirmed arthritis, scoring joint inflammati…

This study tests a new liquid biopsy that measures TB DNA in fluid from around the lungs to diagnose tuberculous pleuritis, a common form of TB. Current methods often require invasive tissue biopsies or have low accuracy. The trial will enroll 350 adults with new-onset pleural ef…

This study tests if giving a low-dose norepinephrine drip just before anesthesia can prevent low blood pressure during emergency surgery for a serious belly infection (peritonitis). About 60 adults with stable blood pressure after initial treatment will be randomly assigned to re…

This observational study will collect detailed information from 150 adults undergoing emergency surgery for complicated diverticulitis. Researchers will analyze factors that influence surgeons' decisions to perform either a primary anastomosis (reconnecting the bowel) or a Hartma…

This study looks at whether analyzing synovial tissue can help doctors better manage pigmented villonodular synovitis (PVNS), a rare joint disease that causes pain and joint damage. Researchers will collect tissue samples from 30 patients through biopsy or surgery to assess quali…

This study will collect data from 10,000 patients across Saudi Arabia who undergo emergency abdominal surgery (laparotomy). Researchers will track complications and deaths within 30 and 90 days after surgery. The goal is to understand current care quality, test international risk…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will test a new scoring system (Mansoura score) to predict a serious bacterial infection called spontaneous bacterial peritonitis in people with liver cirrhosis and fluid buildup in the belly. Researchers will enroll 250 adults to see how well the score identifies who …

This study looks at fluid from peritoneal dialysis to find biological markers that could signal peritoneal fibrosis, a common complication. Researchers will analyze genetic material and metabolites from 55 participants, including dialysis patients and healthy controls. The goal i…