Secondary avascular necrosis

This early-stage study tests a single intravenous dose of a gene therapy called LY3884961 in 15 adults with Gaucher disease type 1. The goal is to see if it is safe and can reduce or replace the need for ongoing enzyme replacement or substrate reduction therapy. Participants must…

This early-phase trial tests a single intravenous dose of LY-M001 gene therapy in 9 children (ages 6 to 17) with type 1 Gaucher disease. The goal is to see if it is safe and can improve key symptoms like liver size and blood markers. Researchers will monitor participants for side…

This trial compares two treatments applied during surgery to help heal jaw bone damage caused by bisphosphonates or similar drugs. One is an oxygen-based gel, the other is a membrane made from the patient's own platelets. Researchers will measure how completely the bone and soft …

This phase 2 trial tests an oral drug called venglustat, given alongside the standard enzyme therapy Cerezyme, in adults with Gaucher disease type 3 (a rare genetic disorder affecting the body and brain). The study has four parts: first, it checks spinal fluid biomarkers to disti…

This study tests whether a graft made from a person's own extracted tooth, with or without low-level laser therapy, helps regrow jawbone after a tooth is pulled. About 21 healthy adults who need at least two back teeth removed and later replaced with implants will take part. The …

This study tests a surgical approach for medication-related osteonecrosis of the jaw (MRONJ), a condition where jaw bone dies after certain drugs. Surgeons use a special ultrasonic device (piezosurgery) to remove dead bone, then close the area with a double-layer flap. Twenty pat…

This phase 3 trial tests whether a combination of pentoxifylline (a muscle pain drug) and vitamin E can help heal jaw bone damage caused by osteoporosis or cancer treatments. About 100 people with medication-related jaw bone death will receive either the drug combo plus standard …

This study tested whether adding injectable Platelet-Rich Fibrin (i-PRF), a natural concentrate from a patient's own blood, to standard deep cleaning improves gum disease outcomes. In 13 adults with moderate to severe periodontitis, one side of the mouth received the combined tre…

This study follows 75 people with Gaucher disease type 1 who previously received FLT201 gene therapy. Researchers will monitor them for 5 years to see if the treatment remains safe and if its effects last. The goal is to understand whether a single dose can provide long-term dise…

This study looks at whether using 3 screws instead of 4 to attach a full lower-jaw dental bridge affects bone loss around the implants. Fourteen men with no teeth in their lower jaw and no major health issues are being followed with X-rays over time. The goal is to see if fewer s…