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Sclerosteosis
MONDO:0017838Sclerosteosis is a very rare serious sclerosing hyperostosis syndrome characterized clinically by variable syndactyly and progressive skeletal overgrowth (particularly of the skull), resulting in distinctive facial features (mandibular overgrowth, frontal bossing, midfacial hypoplasia), cranial nerve entrapment causing facial palsy and deafness, and potentially lethal elevation of intracranial pressure.
Also known as: cortical hyperostosis with syndactyly, cortical hyperostosis-syndactyly syndrome
5 clinical trials for this condition and its sub-types.
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Broader categories
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Gum fluid clues may explain early implant bone loss
Knowledge-focused CompletedThis study examined fluid from around dental implants to find biological markers linked to early bone loss. Researchers compared implants with and without early bone loss in 59 patients. They measured several proteins in the gum fluid to see if any could help explain why some imp…
Sponsor: Pamukkale University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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Gum disease and osteoporosis: hidden link in older women?
Knowledge-focused CompletedThis study examined 80 postmenopausal women to see if there is a connection between gum (periodontal) disease and osteoporosis. Researchers measured two substances in blood and gum fluid called sclerostin and TNF-α, which may help explain how these conditions affect each other. T…
Sponsor: Recep Tayyip Erdogan University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC