Rotavirus infection

This phase 3 study tests whether three doses of an oral rotavirus vaccine (ROTAVAC 5D) can prevent severe diarrhea in healthy infants. Around 4,270 Chilean babies receive either the vaccine or a placebo. Researchers track cases of severe rotavirus gastroenteritis to measure the v…

This early-stage study tested a new inactivated rotavirus vaccine (CDC-9) in 50 healthy adults aged 18 to 45. The goal was to see if the vaccine is safe and triggers an immune response. Participants received three shots over several months and were monitored for side effects and …

This early-stage study tested a new oral rotavirus vaccine in 100 healthy people, from infants to adults. The main goal was to see if the vaccine is safe and well-tolerated. Researchers also checked how well the vaccine triggers an immune response in infants. The study was comple…

This study looked at how effective the Rotarix vaccine is at preventing severe rotavirus infections in children under 6 years old. Researchers enrolled 362 children with acute gastroenteritis at two U.S. hospitals, comparing those who tested positive for rotavirus (cases) with th…

This study tested whether giving the polio vaccine (IPV) at the same time as a rotavirus vaccine (Rotarix PCV-free) is safe and works well in healthy Chinese infants aged 6-10 weeks. About 400 infants received the vaccines either together or a few weeks apart. The main goal was t…

This study tested a new combination vaccine called Shan6™, which protects against six diseases (diphtheria, tetanus, whooping cough, hepatitis B, Hib, and polio) in healthy infants and toddlers in Thailand. The trial involved 460 participants and compared Shan6™ to a similar 5-in…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study looked at whether giving vitamin D to children with rotavirus infection can make their diarrhea and vomiting less severe and shorter. Sixty children with low vitamin D levels were included. Researchers measured symptoms and inflammation markers to see if vitamin D help…

This study looked at whether having better sanitation helps the oral rotavirus vaccine work better in babies. Researchers followed 261 infants in low-income areas of Maputo, Mozambique, comparing those with improved sanitation to those without. They measured immune response and c…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …