Rheumatic disorder
MONDO:0005554Inflammatory and degenerative diseases of connective tissue structures, such as arthritis.
Also known as: rheumatic disease, rheumatologic disorder, collagen disease, collagen vascular disease, connective tissue disease, disease, rheumatic, diseases, rheumatic, enthesopathies
1795 clinical trials for this condition and its sub-types, 91 tagged with Rheumatic disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Rheumatic disorder
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Rheumatoid arthritis 577 trials · 796 incl. sub-types
7 sub-types
- Psoriatic arthritis 188 trials · 201 incl. sub-types Sub-types →
- Ankylosing spondylitis 110 trials · 114 incl. sub-types Sub-types →
- Rheumatoid arthritis-associated interstitial lung disease 12 trials
- Chronic childhood arthritis 5 trials
- Felty syndrome 0 trials
- Polyarticular juvenile rheumatoid arthritis 0 trials
- Rheumatoid vasculitis 0 trials
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Lupus erythematosus 39 trials · 550 incl. sub-types
3 sub-types
- Systemic lupus erythematosus 518 trials · 524 incl. sub-types Sub-types →
- Cutaneous lupus erythematosus 38 trials · 46 incl. sub-types Sub-types →
- Drug-induced lupus erythematosus 1 trial
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Scleroderma 47 trials · 305 incl. sub-types
3 sub-types
- Systemic sclerosis 261 trials · 295 incl. sub-types Sub-types →
- Localized scleroderma 14 trials · 15 incl. sub-types Sub-types →
- Neonatal scleroderma 0 trials
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Autoinflammatory syndrome 21 trials · 207 incl. sub-types
37 sub-types
- Sarcoidosis 61 trials · 84 incl. sub-types Sub-types →
- Periodic fever syndrome 2 trials · 25 incl. sub-types Sub-types →
- Systemic-onset juvenile idiopathic arthritis 25 trials
- Type 1 interferonopathy 4 trials · 21 incl. sub-types Sub-types →
- Autoinflammatory syndrome of childhood 0 trials · 19 incl. sub-types Sub-types →
- VEXAS syndrome 18 trials
- Adult-onset Still disease 12 trials
- Pyoderma gangrenosum 10 trials Sub-types →
- Idiopathic recurrent pericarditis 8 trials
- PFAPA syndrome 6 trials
- Chronic recurrent multifocal osteomyelitis 3 trials · 4 incl. sub-types Sub-types →
- SAPHO syndrome 3 trials
- Schnitzler syndrome 1 trial
- Cherubism 1 trial Sub-types →
- CEBPE-associated autoinflammation-immunodeficiency-neutrophil dysfunction syndrome 0 trials
- F12-associated cold autoinflammatory syndrome 0 trials
- PAPASH syndrome 0 trials
- Pelger-Huet-like anomaly and episodic fever with abdominal pain 0 trials
- SAMD9L-associated autoinflammatory syndrome 0 trials
- Sharpin-related autoinflammatory syndrome 0 trials
- Autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation 0 trials
- Autoinflammatory disease, X-linked 0 trials
- Autoinflammatory disease, multisystem, with immune dysregulation, X-linked 0 trials Sub-types →
- Autoinflammatory disease, systemic, with vasculitis 0 trials
- Autoinflammatory syndrome with immunodeficiency 0 trials
- Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis 0 trials
- Autoinflammatory syndrome, familial, Behcet-like 0 trials Sub-types →
- Autoinflammatory syndrome due to TBK1 deficiency 0 trials
- Early-onset pulmonary and cutaneous vasculitis 0 trials
- Granulomatous autoinflammatory syndrome of childhood 0 trials
- Infantile onset panniculitis with uveitis and systemic granulomatosis 0 trials
- Magic syndrome 0 trials
- Neonatal inflammatory skin and bowel disease 0 trials Sub-types →
- Neonatal-onset severe multisystemic autoinflammatory disease with increased IL18 0 trials
- Psoriasis 14, pustular 0 trials
- Pyoderma gangrenosum-acne-suppurative hidradenitis syndrome 0 trials
- Pyogenic arthritis-pyoderma gangrenosum-acne syndrome 0 trials
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Juvenile idiopathic arthritis 107 trials · 115 incl. sub-types
6 sub-types
- Systemic-onset juvenile idiopathic arthritis 25 trials
- Polyarticular juvenile idiopathic arthritis 14 trials · 16 incl. sub-types Sub-types →
- Psoriasis-related juvenile idiopathic arthritis 15 trials
- Enthesitis-related juvenile idiopathic arthritis 7 trials
- Oligoarticular juvenile idiopathic arthritis 5 trials Sub-types →
- Unspecified juvenile idiopathic arthritis 0 trials
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Dermatomyositis 81 trials · 100 incl. sub-types
11 sub-types
- Juvenile dermatomyositis 41 trials
- Anti-MDA5 dermatomyositis 3 trials
- Clinically amyopathic dermatomyositis 1 trial · 2 incl. sub-types Sub-types →
- Adermatopathic dermatomyositis 0 trials
- Adult dermatomyositis 0 trials
- Anti-Mi2 dermatomyositis 0 trials
- Anti-NXP2 dermatomyositis 0 trials
- Anti-SAE dermatomyositis 0 trials
- Anti-TIF1 dermatomyositis 0 trials
- Classical dermatomyositis 0 trials
- Neonatal dermatomyositis 0 trials
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Polymyalgia rheumatica 30 trials
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Rheumatic fever 17 trials
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Mixed connective tissue disease 15 trials
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Reactive arthritis 6 trials
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Gorham-Stout disease 2 trials
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Sweet syndrome 2 trials
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Palindromic rheumatism 1 trial
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2 sub-types
- Inflammatory bowel disease 25 0 trials
- Inflammatory bowel disease 28 0 trials
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LAMA5-related multisystemic syndrome 0 trials
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Reye syndrome 0 trials
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Wissler syndrome 0 trials
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Acroosteolysis dominant type 0 trials
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Chondrocalcinosis 2 0 trials
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Fibroblastic rheumatism 0 trials
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Idiopathic juvenile osteoporosis 0 trials
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Intermittent hydrarthrosis 0 trials
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Progeria-associated arthropathy 0 trials
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Rheumatic pulmonary valve disease 0 trials
Most studied deeper sub-types
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Community leaders step up to boost COVID shots in black rheumatic patients
Vaccine OngoingThis study tests whether training popular community leaders to share vaccine information can increase COVID-19 booster shots among Black individuals with rheumatic conditions like lupus. About 60 people will take part, including leaders and their social network members. The goal …
Sponsor: Northwestern University • Aim: Vaccine
Last updated Jun 27, 2026 13:00 UTC
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New knee implant tested for better mobility and less pain
Disease control By invitation onlyThis study is testing a new knee implant called the Persona SoluTion PPS femur in 200 adults who need total knee replacement. The goal is to see if it safely improves knee function and reduces pain over two years. Participants will have their knee health measured before surgery a…
Sponsor: Zimmer Biomet • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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New drug SPY002-072 aims to tame multiple inflammatory joint diseases
Disease control OngoingThis Phase 2 study tests an experimental drug called SPY002-072 in 285 adults with moderately to severely active rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis. Participants receive either the drug or a placebo, and researchers measure changes in disease ac…
Phase 2 • Sponsor: Spyre Therapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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Email your doctor to beat gout: new trial tests remote care
Disease control OngoingThis study tests whether regular email communication between gout patients and their doctors can help lower uric acid levels more effectively than standard care. 204 adults with confirmed gout will either follow usual care or use a secure messaging system to adjust their medicati…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Tiny beads aim to quiet arthritic knees without surgery
Symptom relief OngoingThis study tests a new procedure called genicular artery embolization using SakuraBead, a dissolvable bead that blocks small blood vessels in the knee to reduce pain. It involves 89 adults aged 40-79 with moderate to severe knee osteoarthritis that hasn't improved with standard t…
Sponsor: CrannMed • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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New tool could predict who will suffer from steroid side effects
Knowledge-focused OngoingThis study aims to create a tool that predicts which patients with inflammatory rheumatic diseases (like rheumatoid arthritis, vasculitis, or polymyalgia rheumatica) will develop serious side effects from long-term steroid use. Researchers will collect routine medical data—such a…
Sponsor: University Hospital, Brest • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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Your iPhone could help monitor psoriasis: new study tests smartphone tracking
Knowledge-focused OngoingThis study uses an iPhone app to track symptoms of psoriasis and psoriatic arthritis in 1,000 adults. Participants complete surveys, take photos of their skin, and use phone sensors to measure joint function. The goal is to see if smartphones can reliably monitor these conditions…
Sponsor: Sage Bionetworks • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:02 UTC
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New registry aims to unlock safer pregnancies for women with autoimmune conditions
Knowledge-focused By invitation onlyThis registry enrolls up to 1,000 women aged 12–55 with rheumatic or autoimmune diseases who are pregnant or planning pregnancy. Researchers will collect data from medical records and patient surveys to study pregnancy outcomes, disease activity, and medication use. No experiment…
Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Can rheumatic patients safely get multiple vaccines at once? new study investigates
Knowledge-focused OngoingThis study looks at how well COVID-19 booster vaccines work in people with rheumatic diseases (like arthritis) who take medications that affect their immune system. Researchers want to see if getting the COVID-19 booster at the same time as other routine vaccines (like tetanus or…
Phase 4 • Sponsor: Oregon Health and Science University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Hidden swallowing risks found in rheumatic disease patients?
Knowledge-focused OngoingThis study checks how common swallowing difficulties (dysphagia) are in people with inflammatory rheumatic diseases like rheumatoid arthritis. Researchers used questionnaires to measure swallowing function, gut symptoms, and diet quality in 191 participants. The goal is to unders…
Sponsor: Pamukkale University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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New digital tool aims to cut medical errors during hospital transfers
Knowledge-focused By invitation onlyThis study tests a new digital platform that helps doctors and nurses share important patient information when a person is moved from one hospital to another. About 1,000 adults being transferred to a major hospital will take part. The goal is to see if better information sharing…
Sponsor: Brigham and Women's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC
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Trauma tied to fibromyalgia? new study investigates
Knowledge-focused By invitation onlyThis study looks at whether stressful or traumatic life events increase the chance of developing fibromyalgia. Researchers will follow 534 adults—some with rheumatic diseases and some healthy—for one year, checking for new fibromyalgia cases. The goal is to better understand how …
Sponsor: National Institute of Medical Sciences and Nutrition, Salvador Zubiran • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC
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500 obese adults donate samples to unlock secrets of weight loss
Knowledge-focused OngoingThis study collects blood, urine, and tissue samples from 500 obese adults to help researchers understand why people gain weight, lose weight, or regain weight after treatment. Participants must be over 18 with a BMI of 30 or higher. The samples will be stored for up to 10 years …
Sponsor: Pichamol Jirapinyo, MD, MPH • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Scientists track how aging changes arthritis symptoms and thinking skills
Knowledge-focused OngoingThis study looks at how getting older affects disease activity, memory, and physical function in people with rheumatoid arthritis (RA) compared to those without RA. Researchers will follow 840 adults aged 55-85, half with RA and half without, using questionnaires and physical tes…
Sponsor: Maastricht University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC