Primary aldosteronism
MONDO:0001422An endocrine disorder characterized by excessive production of aldosterone by the adrenal glands. Causes include adrenal gland adenoma and adrenal gland hyperplasia. The overproduction of aldosterone results in sodium and water retention and hypokalemia. Patients present with high blood pressure, muscle weakness, and headache.
Also known as: Conn syndrome, Conn's syndrome, primary aldosteronism, primary hyperaldosteronism
49 clinical trials for this condition and its sub-types.
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Broader categories
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New needle treatment could replace surgery for curing Hormone-Driven high blood pressure
⭐️ CURE ⭐️ OngoingThis study tests if a less invasive needle-based treatment (thermal ablation) works as well as surgery to cure a hormone disorder called primary aldosteronism, which causes high blood pressure. About 122 adults with the condition will be randomly assigned to one of the two treatm…
Phase: NA • Sponsor: Queen Mary University of London • Aim: ⭐️ CURE ⭐️
Last updated Jul 19, 2026 00:00 UTC
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Non-invasive scan could replace risky procedure for adrenal tumor diagnosis
Diagnosis OngoingThis study tests a special PET scan (11C-Metomidate) to better identify adrenal tumors that cause high blood pressure and can be cured with surgery. About 100 adults with suspected adrenal-related hypertension will receive the scan, which is non-invasive and may replace the curre…
Phase: PHASE2, PHASE3 • Sponsor: Changi General Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 08:01 UTC
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Wearable tech puts hormone health to the test
Knowledge-focused OngoingThis trial tests whether wearable devices can measure how the body responds to everyday challenges like changes in salt intake, meals, fasting, and exercise in adults with endocrine or metabolic disorders. Participants wear home monitoring devices and follow different diet and ac…
Phase: NA • Sponsor: Felix Beuschlein • Aim: Knowledge-focused
Last updated Jul 29, 2026 00:00 UTC
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Gene clue could lead to surgical cure for some high blood pressure patients
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at a specific genetic change found in some people with high blood pressure. Researchers want to see if this change is linked to a condition called primary aldosteronism, which can sometimes be cured with surgery. About 76 men from a larger Swedish health study wh…
Phase: NA • Sponsor: Linkoeping University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Heart risks in adrenal tumor patients under the microscope
Knowledge-focused ENROLLING_BY_INVITATIONThis study follows 150 patients with functional adrenal tumors to see how their heart and blood pressure change before and after surgery. Researchers will use heart ultrasounds and blood pressure monitoring to understand recovery and risks. The goal is to help doctors choose bett…
Sponsor: Peking University First Hospital • Aim: Knowledge-focused
Last updated Jun 26, 2026 19:09 UTC