Primary aldosteronism
MONDO:0001422An endocrine disorder characterized by excessive production of aldosterone by the adrenal glands. Causes include adrenal gland adenoma and adrenal gland hyperplasia. The overproduction of aldosterone results in sodium and water retention and hypokalemia. Patients present with high blood pressure, muscle weakness, and headache.
Also known as: Conn syndrome, Conn's syndrome, primary aldosteronism, primary hyperaldosteronism
48 clinical trials for this condition and its sub-types.
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Broader categories
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Zapping adrenal tumors could lower blood pressure without surgery
Disease control CompletedThis study tested a procedure called radiofrequency ablation, which uses heat to destroy a small adrenal gland tumor that causes high blood pressure. Researchers wanted to see if it could safely lower blood pressure in 31 patients with primary aldosteronism. The goal was to reduc…
Phase: NA • Sponsor: University Hospital, Toulouse • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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New pill shows promise for controlling blood pressure in rare hormone disorder
Disease control CompletedThis study tested a new drug called CIN-107 in 15 adults with primary aldosteronism, a condition where the body makes too much of a hormone that raises blood pressure. Participants took the drug once daily for up to 12 weeks to see if it safely lowered blood pressure. The goal wa…
Phase: PHASE2 • Sponsor: AstraZeneca • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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New hope for Hard-to-Control blood pressure: finerenone shows promise
Disease control CompletedThis study tested a drug called finerenone in 55 adults with primary aldosteronism, a condition where the adrenal glands make too much aldosterone, leading to high blood pressure. The goal was to see if finerenone can safely lower blood pressure over 12 weeks. Participants starte…
Phase: PHASE4 • Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School • Aim: Disease control
Last updated Jun 26, 2026 16:02 UTC
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New blood test thresholds could sharpen diagnosis of hidden high blood pressure cause
Diagnosis CompletedThis study looked at 105 people to find the best blood test values for diagnosing primary hyperaldosteronism, a condition where the adrenal glands make too much aldosterone hormone, causing high blood pressure. Researchers measured aldosterone and renin levels using advanced lab …
Phase: NA • Sponsor: University Hospital, Caen • Aim: Diagnosis
Last updated Jun 28, 2026 00:00 UTC
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Simple blood test could uncover curable high blood pressure
Diagnosis CompletedThis study tested whether a simple blood test, called the aldosterone renin ratio (ARR), could help doctors find more cases of primary aldosteronism—a common but often missed cause of high blood pressure that can be cured with surgery or treated with specific medications. Researc…
Sponsor: The Cleveland Clinic • Aim: Diagnosis
Last updated Jun 27, 2026 09:08 UTC
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Researchers measure breathing, strength, and quality of life in hospitalized endocrine patients
Knowledge-focused CompletedThis completed observational study at Uşak University examined 150 adults hospitalized in the endocrinology department. Researchers measured breathing, muscle strength, pain, fatigue, sleep quality, physical activity, balance, and nerve function. The goal was to better understand…
Sponsor: Uşak University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC