Posterior leukoencephalopathy syndrome
MONDO:0044033An acute or subacute reversible condition characterized by headaches, mental status changes, visual disturbances, and seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment.
Also known as: PRES, Posterior reversible encephalopathy syndrome, RPLE, posterior reversible encephalopathy syndrome, reversible Posterior cerebral edema syndrome, reversible Posterior cerebral oedema syndrome, reversible Posterior leukoencephalopathy syndrome, reversible occipital parietal encephalopathy
31 clinical trials for this condition and its sub-types.
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Could vinegar and fasting fix prediabetes cholesterol?
Disease control CompletedThis study tests whether taking date cider vinegar daily, alone or combined with 5:2 intermittent fasting, can improve cholesterol and other metabolic measures in adults with prediabetes and mild to moderate high cholesterol or blood pressure. Participants are randomly assigned t…
Phase: NA • Sponsor: University of Lahore • Aim: Disease control
Last updated Jul 19, 2026 00:00 UTC
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One-Stop care: hepatitis c treatment may curb HIV and opioid risks
Disease control CompletedThis study tested a new way to care for people who inject drugs and have hepatitis C. Along with standard hepatitis C treatment, participants were offered HIV prevention medication and buprenorphine for opioid use disorder. The goal was to see if this combined approach could cure…
Sponsor: University of Maryland, Baltimore • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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New program aims to protect young kenyan women from both HIV and partner violence
Prevention CompletedThis study tests a program called Tu'Washindi, designed by and for young women in Kenya. It combines support clubs and community sessions to help girls ages 15-24 reduce intimate partner violence and consistently use HIV prevention pills (PrEP). About 1,562 participants will be f…
Phase: NA • Sponsor: RTI International • Aim: Prevention
Last updated Aug 09, 2026 00:00 UTC
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HIV prevention pills offered in the ER: a small step forward
Prevention CompletedThis pilot study tested whether offering HIV prevention medication (PrEP) in the emergency department is feasible. 26 adults at high risk for HIV were enrolled. The goal was to see if people would start PrEP and follow up with a clinic within 30 days. The study aimed to overcome …
Phase: NA • Sponsor: Icahn School of Medicine at Mount Sinai • Aim: Prevention
Last updated Jun 27, 2026 08:03 UTC
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Can a plastic device or a skin tap make shots less scary for kids?
Symptom relief CompletedThis study tested two non-drug methods to reduce pain, fear, and anxiety in children aged 4 to 6 getting intramuscular injections in a pediatric emergency department. One method used a flat, bumpy plastic device called ShotBlocker pressed against the skin before the shot. The oth…
Phase: NA • Sponsor: Sakarya University • Aim: Symptom relief
Last updated Jun 27, 2026 08:07 UTC
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Can smarter surveys improve your doctor visit?
Knowledge-focused CompletedThis study tested a new strategy for collecting patient-reported outcome measures (PROMs) to make them more relevant and less burdensome. Researchers compared usual PROMs with an enhanced version in 200 English- and Spanish-speaking patients. The goal was to see if the new approa…
Phase: NA • Sponsor: University of Texas at Austin • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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New tool measures the Real-Life impact of vaginal aging in portuguese women
Knowledge-focused CompletedThis study tested a Portuguese version of the DIVA questionnaire to see if it reliably measures how vaginal aging symptoms (like dryness, itching, or pain) affect daily activities, sex life, emotions, and body image. 300 women with at least one symptom of vulvovaginal atrophy too…
Sponsor: Instituto Politécnico de Leiria • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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Knee surgery outcomes under review for complex ligament tears
Knowledge-focused CompletedThis study looked at 42 people who had surgery for multiple torn knee ligaments between 2000 and 2019. Researchers measured knee function and symptoms using standard questionnaires. The goal was to understand how well surgery works for these serious injuries, which can cause long…
Sponsor: Istituto Ortopedico Rizzoli • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Dental implants under the microscope: what happens years later?
Knowledge-focused CompletedThis study followed 163 people who got dental implants between 1999 and 2005 to see how well the implants held up over time. Researchers checked patient satisfaction, implant survival, bone loss, and signs of inflammation. They also looked for risk factors that might lead to prob…
Sponsor: Folktandvården Stockholms län AB • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC