Pleural empyema

This phase 3 trial tests whether early irrigation of the chest cavity with saline can improve outcomes for people with complicated pleural infections. 244 adults will receive either standard care or saline irrigation twice daily for three days. The goal is to see if this approach…

This study tests two different drug combinations for pleural infection, a serious infection of the lung lining that often requires surgery. The standard treatment uses two drugs (alteplase and DNase) given through a chest tube. This trial compares that to a new combination using …

This study tests whether washing the chest cavity with the antifungal drug voriconazole can help treat a rare but serious fungal infection of the lung lining. It includes 50 patients who either get the wash before surgery or as a standalone treatment if they are too sick for surg…

This study tests whether treating pleural empyema (a serious lung infection with pus in the chest cavity) with a drain and medication works as well as surgery. 184 adults with advanced-stage empyema will be randomly assigned to either video-assisted surgery or a less invasive app…

This study tests whether giving medication once a day through a chest tube works as well as giving it twice a day for people with serious infections around the lungs. Participants are adults already in the hospital with a chest tube draining infected fluid. They will be randomly …

This study looks at whether adding a simple saltwater rinse (saline irrigation) through a chest tube can improve how well the standard medication clears a serious lung infection called empyema. About 60 adults with this infection will receive either standard treatment alone or st…

This study looks at whether regularly flushing chest drains with salt water helps keep them from getting blocked in people with serious lung infections (empyema). The goal is to see if this simple step can shorten the time the drain needs to stay in, reduce hospital stays, and im…

This study tests whether a lower dose (2.5 mg) of a clot-busting drug called tPA works as well as the standard dose (10 mg) for treating pleural infections, which cause fluid buildup around the lungs. The drug is given through a chest tube along with another enzyme to help drain …

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…