Perennial allergic rhinitis

This early-stage study tests a new vaccine called PollenVax for people with moderate to severe mugwort pollen allergy. The main goal is to see if the vaccine is safe and tolerable in 30 adults aged 18 to 65. Participants receive four shots of either the vaccine or a placebo, and …

This study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…

This study tested whether analyzing a patient's DNA and RNA could help doctors pick the right drug for inflammatory diseases that don't fit standard categories. 32 adults with at least two affected organs (including skin) received one of six targeted therapies based on their mole…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

This study tested whether adding thread embedding acupuncture (TEA) to standard steroid nasal spray helps people with allergic rhinitis. 64 adults took part. The goal was to see if the combination reduces symptoms like sneezing and stuffy nose better than the spray alone, and whe…

This study tested whether adding a decongestant nasal spray for the first 5 days to standard steroid spray treatment helps children with persistent allergic rhinitis feel better faster. 76 children aged 4-18 were randomly assigned to receive either steroid spray alone for 4 weeks…

This study tested an experimental nasal spray called INI-2004 in 78 adults with ragweed allergies. Participants received either the spray or a placebo once a week for four weeks, then spent time in a room filled with ragweed pollen to see if symptoms improved. The goal was to che…

This study looked at whether giving a low dose of a muscle relaxant (rocuronium) during bronchoscopy—a procedure where a tube is inserted into the lungs—could reduce complications like throat spasms and coughing. 153 adults having elective bronchoscopy were split into two groups:…

This study tested the safety and effectiveness of Allegra D (fexofenadine plus pseudoephedrine) in 203 people aged 12 and older with allergic rhinitis. Participants took the medication for up to 13 days, and researchers tracked side effects and symptom improvement using nasal and…

This study tested whether apple fruit extract, which has antioxidant and anti-inflammatory properties, could improve symptoms of allergic rhinitis (hay fever). Forty adults with persistent allergies received either standard treatment plus apple extract or standard treatment alone…

This study tested whether the drug TAU-284 (bepotastine besilate) can reduce sneezing, runny nose, and congestion in children aged 7 to 15 with perennial allergic rhinitis (year-round nasal allergies). In a double-blind, placebo-controlled design, 473 children took either the dru…

This study tested a medicine called TAU-284 in 490 children aged 7 to 15 who have year-round nasal allergies. The goal was to see if it reduces sneezing, runny nose, and congestion better than a placebo. The trial was completed and focused on symptom relief, not a cure.

This study tested the long-term safety and effectiveness of TAU-284 (bepotastine besilate) in 58 children aged 7 to 15 with perennial allergic rhinitis (year-round nasal allergies). Over 12 weeks, researchers tracked side effects and changes in sneezing, runny nose, and congestio…

This study looked at whether children with year-round allergic rhinitis can use a nasal steroid spray only when symptoms bother them, instead of every day. Sixty-eight children aged 6 to 18 were randomly assigned to either daily use or as-needed use of fluticasone furoate spray. …

This study tested a nasal spray called AD17002 in 48 adults with house dust mite allergic rhinitis. The goal was to see if it is safe and can reduce symptoms like sneezing, runny nose, and congestion. Participants received either the spray or a placebo, and researchers monitored …

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This completed study looked at whether substances in nasal fluid can help doctors objectively measure the severity of respiratory conditions like asthma, COPD, hayfever, and sinusitis. Researchers collected samples from 111 adults (including healthy volunteers) using a small nasa…

This completed Phase 1 study tested whether two substances in the blood (sST2 and miR-223) can help predict how well patients with dust mite allergies respond to a six-month course of under-the-tongue immunotherapy (SLIT). Fifty-four patients with moderate-to-severe allergic rhin…

This study collected blood, saliva, stool, urine, and skin samples from 19 people with unknown or poorly understood immune system problems. The goal was to learn how different parts of the immune system work together. No treatments or drugs were tested. Participants were followed…