Osteomyelitis

This study tests whether adding a bone-strengthening drug (bisphosphonate) to a standard antibiotic (vancomycin) can better control chronic bone infections that are hard to treat. About 280 adults with a specific type of bone infection will be randomly assigned to get either the …

This study tests whether the drug zoledronate can reduce pain in children aged 4 to 17 with chronic recurrent multifocal osteomyelitis (CRMO), a rare auto-inflammatory bone disease. The 30 participants have not responded to standard anti-inflammatory drugs. They will receive eith…

This study looks at how the antibiotic delafloxacin spreads through the body in 20 adults with serious skin, soft tissue, bone, or joint infections. Researchers will measure drug levels in blood and in tissues collected during surgery. The goal is to understand if the drug reache…

This study will collect detailed information from 2000 people with osteomyelitis (a serious bone infection) to help doctors learn which treatments work best. Participants will be followed for at least 8 weeks after treatment to check if the infection is gone. The goal is to creat…

This study will follow 100 adults with diabetes and foot ulcers to see how non-vascular factors like nerve damage, infection, and poor blood sugar control affect ulcer severity and healing. Researchers hope to find which risk factors can be changed to prevent ulcers from coming b…