Normal pressure hydrocephalus

This study tests whether the ShuntCheck device can accurately tell if a shunt is flowing or blocked in people with normal pressure hydrocephalus who have no symptoms. The device uses a gentle heat sensor on the skin to check flow. 50 adults with shunts will be tested during routi…

This study compares a device called ShuntCheck, which uses heat to measure fluid flow through a shunt, to the standard nuclear medicine test for detecting blockages. Researchers will enroll 20 adults aged 40 and older with normal pressure hydrocephalus who have a shunt and are su…

This study tests a new MRI technique to measure how cerebrospinal fluid flows in the brain. Researchers will compare 50 healthy volunteers and patients with conditions like Alzheimer's disease or normal pressure hydrocephalus. The goal is to improve diagnosis and understanding of…

This study tests whether a gentle, non-invasive brain stimulation technique called tACS can improve memory and thinking in people with Alzheimer's disease, frontotemporal dementia, Lewy body dementia, and related conditions. Two hundred participants will receive either real or sh…

This study is testing a device called Intellidrop that automatically drains fluid from the spine during a standard test for normal pressure hydrocephalus (NPH). The device monitors pressure and controls drainage, which may reduce errors and make the process more comfortable for p…

This study follows 140 people with early signs of normal pressure hydrocephalus (NPH) to see if brain scans and fluid tests can predict who will get worse and need shunt surgery. Participants include those with mild symptoms, those with clear NPH, and healthy volunteers. The goal…

This study is investigating why some patients with normal pressure hydrocephalus (a condition that causes walking problems, memory loss, and incontinence) improve after a shunt surgery that drains extra fluid from the brain. Researchers will analyze proteins in the spinal fluid o…

This study looks at whether certain proteins in spinal fluid can predict which adults with chronic hydrocephalus will improve after a shunt surgery. About 150 participants will have their fluid tested for amyloid and tau proteins, then tracked for changes in thinking, walking, an…

This study looks at how sleep apnea changes pressure in the brain and belly during sleep in people with normal-pressure hydrocephalus. Researchers want to see if these pressure changes affect how well a surgically placed shunt (a tube that drains fluid from the brain) works. The …

This study is gathering information from 4500 people who have or will have brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find patterns that help doctors predict how well someone will recover. By standardizing how outcomes a…

This study looks at 100 older adults with normal pressure hydrocephalus (NPH) to find out why some get better after a shunt surgery and others do not. Researchers will use brain scans, blood tests, and wearable monitors to check for nerve damage and signs of dementia. The goal is…

This study tests a non-invasive light-based device to measure blood flow and oxygen use in the brains of premature infants who have bleeding or fluid buildup. Researchers will compare these measurements in affected babies, those with other types of fluid buildup, and healthy newb…

This study is gathering information from 700 people with Parkinson's disease or similar conditions who experience freezing of gait—a sudden inability to move their feet while walking. Researchers will track symptoms, walking patterns, and falls over three years using questionnair…

This lab study uses leftover spinal fluid from 10 patients with normal pressure hydrocephalus to see if common numbing medicines form crystals. Researchers mix different drugs and watch for crystals over 60 minutes. The goal is to understand risks, not to treat patients directly.

This study looks at whether using a mix of brain scans, spinal fluid tests, and thinking/movement assessments can better diagnose idiopathic normal pressure hydrocephalus (iNPH) and identify who will benefit from shunt surgery. Researchers will follow 116 adults aged 60+ with sus…