Spinal fluid test may predict shunt success in hydrocephalus patients
NCT ID NCT05915000
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether certain proteins in spinal fluid can predict which adults with chronic hydrocephalus will improve after a shunt surgery. About 150 participants will have their fluid tested for amyloid and tau proteins, then tracked for changes in thinking, walking, and brain size after the procedure. The goal is to reduce the 20-25% of patients who currently get little to no benefit from the surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this could help doctors identify which patients are most likely to improve after shunt surgery, avoiding unnecessary procedures for those who won't benefit.
- What could go wrong
- This is an observational study, not a treatment trial. It may not find clear protein markers, and results may not change current practice for years.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hospital General Universitario de Valencia
RECRUITINGValencia, Valencia, 46015, Spain
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Vicente Vanaclocha
RECRUITINGValencia, Valencia, 46015, Spain