Mood disorder

This phase 2 trial is testing whether an experimental drug called BMS-986511 can reduce symptoms of major depressive disorder in adults. Participants with moderate to severe depression will receive either the drug or a placebo, and researchers will track changes in depression sco…

This phase 3 trial tests whether adding an experimental drug called brenipatide to standard depression treatment can delay the return of major depressive symptoms in adults with major depressive disorder. Participants receive either brenipatide or a placebo by injection, alongsid…

This pilot trial tests whether a single session of personalized brain stimulation, called PandA-tACS, is safe and tolerable for pregnant women with depression. Researchers will compare it to a standard brain stimulation method and a sham (placebo) to see if it changes brain activ…

This trial tests whether wearing lavender-sandalwood aromatherapy tabs for 24 hours can improve mood, reduce pain, and increase satisfaction in women recovering from a scheduled cesarean section. Participants wear the scented tabs on their hospital gown and complete mood and pain…

This trial tests whether taking a daily capsule of Nepalese pepper extract (Zanthoxylum armatum) for 42 days can improve cognitive speed, reduce mental fatigue, and enhance gaming performance in healthy young action video gamers aged 16 to 39. Participants will take either the pe…

This 12-week trial tests whether a two-part dietary supplement system — a PM powder taken before bed and AM capsules taken with breakfast — can improve sleep quality, mood, mental clarity, and digestive comfort in generally healthy adults aged 18 to 65 who have trouble sleeping. …

This pilot study tests whether MyFILM, a 9-week group program using clips from the movie Inside Out, is feasible and acceptable for children aged 9-12 with mood or anxiety concerns. Participants attend weekly sessions to learn social-emotional skills and coping strategies. The st…

This study tests an online platform called PURSUIT that teaches coping skills to Michigan youth aged 8-18 and their caregivers. The program provides cognitive-behavioral techniques for managing pain, stress, and mood, with extra substance use prevention content for teens 12 and o…

This study investigates whether a single session of whole-body hyperthermia (using an infrared sauna) can quickly improve symptoms of depression and anxiety. Researchers will measure brain activity, inflammation, and mood changes in four groups: healthy postpartum women, postpart…

This study will test whether Reiki therapy, a gentle hands-on energy technique, can improve recovery, comfort, and mood in women who have had a cesarean section. Eighty new mothers will receive three Reiki sessions on days 1, 2, and 7 after birth, in addition to standard care. Re…

This study tests whether a type of cognitive training called Action-Based Cognitive Remediation (ABCR) can improve thinking skills in people with various psychiatric conditions like depression, schizophrenia, anxiety, PTSD, and autism. Participants will complete computer exercise…

This study tests whether a single 'Braining' group exercise session can quickly reduce anxiety in people receiving psychiatric care. Thirty participants will rate their anxiety before and after the session. The goal is to see if exercise can be a fast-acting tool to ease symptoms…

This pilot study tests whether a one-day online cognitive behavioral therapy (CBT) workshop can help women with postpartum depression in Türkiye. Sixty mothers with depressive symptoms will be randomly assigned to either the workshop or usual care. The study focuses on whether th…

This pilot study tests whether a daily lemon balm supplement can improve mood and reduce stress in healthy adults. Forty volunteers will take either the supplement or a placebo for 3 weeks. Researchers will measure changes in stress perception and cortisol levels.

This study tests a blackcurrant-based drink called Ārepa to see if it helps thinking and mood during simulated high altitude (4,500 meters). Twenty-seven healthy men will take the drink or a placebo in random order, then do thinking tasks and have their heart rate, oxygen levels,…

This study aims to find better ways to diagnose bipolar disorder and predict when mood episodes might happen. Researchers will track sleep, activity, and decision-making in 600 people with bipolar disorder, major depression, or healthy controls using smartwatches and computer tas…

This study will create a large biobank of blood samples and detailed health information from 1,000 people with bipolar disorder in Turkey. Researchers will collect DNA and clinical data to better understand the condition and find genetic clues that could improve diagnosis and tre…