Lupus nephritis

This early-stage trial tested a drug called itolizumab (EQ001) in 52 adults with lupus, some of whom also had active kidney inflammation. The main goal was to check safety and find the right dose. Researchers also looked at how the drug behaves in the body and how it affects immu…

This study tested whether analyzing a patient's DNA and RNA could help doctors pick the right drug for inflammatory diseases that don't fit standard categories. 32 adults with at least two affected organs (including skin) received one of six targeted therapies based on their mole…

This study looked back at medical records of 56 adults with lupus nephritis to compare two drugs: telitacicept and belimumab. The goal was to see which drug better protects kidney function and causes fewer side effects. Participants had already been on one of the drugs for at lea…

This phase 2 study tested the drug efgartigimod in 73 Chinese patients with active lupus nephritis, a serious kidney complication of lupus. Participants received either the drug or a placebo by IV infusion over 24 weeks. The main goal was to see if the drug could reduce protein i…

This study tested a new drug called KZR-616 (zetomipzomib) in 69 people with lupus, some of whom also had kidney inflammation (lupus nephritis). Participants received weekly injections for 13 or 24 weeks. The main goals were to check safety and see if the drug could reduce protei…

This study tested three doses of a drug called BI 655064 in 121 people with active lupus nephritis, a kidney complication of lupus. The goal was to see if the drug, given as a shot under the skin, could improve kidney function after one year when added to standard treatments. The…

This study tested two different drug combinations for people with active lupus nephritis, a serious kidney condition caused by lupus. It compared tacrolimus plus steroids against mycophenolate mofetil plus steroids. The goal was to see which combination better controlled kidney d…

This study looked at whether people with lupus-related kidney inflammation (lupus nephritis) who have been stable for two years can safely stop taking immunosuppressive drugs like mycophenolate mofetil or azathioprine. One hundred patients were split into two groups: one continue…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested a new wearable patch that collects sweat to measure sodium and creatinine levels, which are important for monitoring kidney health and dehydration. Five adults with kidney disease wore the patch while their sweat was analyzed using a special light-based techniqu…

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

This study followed 69 people in Taiwan with lupus nephritis who were newly prescribed the drug Myfortic (mycophenolate sodium). Researchers tracked side effects and reasons for stopping the drug over 12 months. The goal was to understand the drug's safety in this specific popula…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study looked at whether a specific antibody, called anti-GBM, could be a useful marker for lupus nephritis—a serious kidney complication of lupus. Researchers tested stored blood samples from 100 people with lupus (some with kidney issues, some without) and compared them to …

This study looked at 193 people with lupus nephritis (kidney inflammation caused by lupus) in five Gulf countries. Researchers collected information on their symptoms, treatments, and quality of life, but did not test any new medicine. The goal was to better understand the diseas…