Long QT syndrome
MONDO:0002442A condition that is characterized by episodes of fainting (syncope) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are Romano-Ward syndrome (also known as long QT syndrome 1) and Jervell-Lange Nielsen syndrome.
Also known as: long QT syndrome, ventricular arrhythmia associated with long QT syndrome
25 clinical trials for this condition and its sub-types.
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Broader categories
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New IVF medium may help those with low fertilization rates
Disease control CompletedThis study tested a ready-to-use calcium ionophore medium (GM508 CultActive) on eggs from 68 IVF patients who had low fertilization rates, poor embryo quality, or were over 40. The medium was applied shortly after sperm injection to try to improve fertilization and embryo develop…
Phase: NA • Sponsor: Chang Gung Memorial Hospital • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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Single-Patient trial tests heart drug for rare genetic syndrome
Symptom relief CompletedThis study tested whether a single intravenous dose of diltiazem, a calcium channel blocker, can shorten the QT interval in adults with Jervell and Lange-Nielsen syndrome, a rare genetic heart condition that increases the risk of dangerous heart rhythms. Only one person participa…
Phase: PHASE4 • Sponsor: Vanderbilt University Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
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Heart conditions in kids: study reveals impact on daily life and play
Knowledge-focused CompletedThis study looks at how inherited heart rhythm problems (like Long QT Syndrome) and heart muscle diseases (like Hypertrophic Cardiomyopathy) affect the quality of life and physical activity of children aged 6 to 18. Researchers will compare 107 children with these conditions to 1…
Phase: NA • Sponsor: University Hospital, Montpellier • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Hormone shield: could progesterone or testosterone guard against Drug-Induced heart risks?
Knowledge-focused CompletedThis study looked at whether taking progesterone (in women) or testosterone (in men) could reduce dangerous changes in heart rhythm caused by certain medications. 73 healthy older adults (postmenopausal women and men 65+) took either the hormone or a placebo, then received a smal…
Phase: PHASE4 • Sponsor: Indiana University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC