Keratoconus

This study tests whether treating donor corneal tissue with a cross-linking procedure before transplant can improve vision and reduce astigmatism in people with keratoconus. About 216 adults aged 18–50 who need a corneal transplant will receive either cross-linked or standard don…

This pilot study tests a procedure called PRK-Plus, which combines laser vision correction with corneal cross-linking to treat thin, suspicious corneas. The goal is to improve vision and strengthen the cornea to prevent future problems. Sixty participants with thin corneas and ce…

This study will develop and test an artificial intelligence system to detect common eye diseases like glaucoma, cataracts, and diabetic retinopathy using 15,000 existing eye images from Costa Rican patients. The goal is to create a tool that works accurately for local populations…

This study checks if a special thinking test (MoCA Blind) can find memory or thinking problems after cornea surgery. It includes 200 adults with cornea disease who will take the test before and 90 days after surgery. The goal is to give doctors a better way to spot these issues i…

This early study tests a special contact lens that has a tiny pinhole built in. The idea is that the pinhole helps focus light better, improving vision for people with presbyopia (age-related blurry near vision) or keratoconus (a cone-shaped cornea). Sixteen adults will try the l…

This study will follow 100 people with keratoconus or corneal ectasia who undergo CTAK surgery. Researchers will use a questionnaire before and after surgery to measure changes in vision quality and overall quality of life. The goal is to see if this surgical approach helps patie…

This study will measure eye pressure in one person with mild keratoconus before and one month after corneal cross linking. The goal is to see how the treatment changes eye pressure using a special device called Corvis CT. This is an observational study, not a treatment trial.

This study will follow 421 people with keratoconus, a condition that thins and bulges the cornea, to learn how it progresses and what factors increase risk. Researchers will use eye exams and imaging to track changes over time. The goal is to improve how doctors manage the diseas…